ArticleJournal of motor behavior2014
Individualized brain inhibition and excitation profile in response to paired-pulse TMS.
Article in Journal of motor behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Central Post-Stroke Pain: An Integrative Review of Somatotopic Damage, Clinical Symptoms, and Neurophysiological Measures.Frontiers in neurology · 2021Pooled it
- Effects of acute resistance training modality on corticospinal excitability, intra-cortical and neuromuscular responses.European journal of applied physiology · 2017Trial
- Low-Frequency Repetitive Transcranial Magnetic Stimulation Targeted to Premotor Cortex Followed by Primary Motor Cortex Modulates Excitability Differently Than Premotor Cortex or Primary Motor Cortex Stimulation Alone.Neuromodulation : journal of the International Neuromodulation Society · 2015Trial
- A Systematic Review of Functional Brain Imaging Studies in Neurofibromatosis 1.Neuropsychology review · 2026Review
- Assessing SICI Cortical Inhibition With DLPFC TMS-EEG Using Different ISI Values.Psychophysiology · 2026Article
- The pathobiology of psychomotor slowing in psychosis: altered cortical excitability and connectivity.Brain : a journal of neurology · 2024Article
- When the heart inhibits the brain: Cardiac phases modulate short-interval intracortical inhibition.iScience · 2024Article
- Cortical Sensorimotor Integration as a Neural Origin of Impaired Grip Force Direction Control following Stroke.Brain sciences · 2024Article
- Motor potentials evoked by transcranial magnetic stimulation: interpreting a simple measure of a complex system.The Journal of physiology · 2023Review
- Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke.Frontiers in neuroscience · 2023Review
- Neuroprotective Effects of Intermittent Theta Burst Stimulation in Parkinson's Disease (NET-PD): A Study Protocol for a Delayed-Start Randomized Double-Blind Sham-Controlled Trial.Journal of clinical medicine · 2022Article
- Tracking cortical excitability dynamics with transcranial magnetic stimulation in focal epilepsy.Annals of clinical and translational neurology · 2022Article
- Reduced Cerebellar Brain Inhibition Measured Using Dual-Site TMS in Older Than in Younger Adults.Cerebellum (London, England) · 2022Article
- Effects of Remote Ischemic Conditioning on Hand Engagement in individuals with Spinal cord Injury (RICHES): protocol for a pilot crossover study.F1000Research · 2021Article
- Good test-retest reliability of a paired-pulse transcranial magnetic stimulation protocol to measure short-interval intracortical facilitation.Experimental brain research · 2020Article
- Spatiotemporal Dynamics of Single and Paired Pulse TMS-EEG Responses.Brain topography · 2020Article
- Application of long-interval paired-pulse transcranial magnetic stimulation to motion-sensitive visual cortex does not lead to changes in motion discrimination.Neuroscience letters · 2020Article
- Aberrant Middle Prefrontal-Motor Cortex Connectivity Mediates Motor Inhibitory Biomarker in Schizophrenia.Biological psychiatry · 2019Article
- Cerebellar-Stimulation Evoked Prefrontal Electrical Synchrony Is Modulated by GABA.Cerebellum (London, England) · 2018Article
- Test-retest reliability of short-interval intracortical inhibition and intracortical facilitation in patients with schizophrenia.Psychiatry research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) are generated from paired-pulse transcranial magnetic stimulations (ppTMS) using certain interstimulus intervals (ISIs). ppTMS provides an accessible technique to evaluate inhibitory and facilitatory motor neural circuits. However, SICI and ICF are highly variable such that individual variability is not captured by any one static ISI. The authors hypothesized that individuals may have individualized and relatively stable pattern of SICI-ICF profiles. They tested SICI and ICF profiles using ISIs from 1 to 500 ms, on 2 occasions about 3 weeks apart, and the test-retest reliability, in 23 healthy controls. Moderate-to-good test-retest reliabilities were found at ppTMS with 1 and 3 ms ISIs (SICI) and with 12, 15, 18, and 21 ms ISIs (ICF), but not with other control ISIs. A similar pattern of results was obtained for men and women. Interestingly, the peak facilitation, peak inhibition, and maximum inhibition and facilitation ranges were individualized, such that they varied considerably across individuals but had high repeatability within individual (Cronbach's α = 0.76 to 0.85). Therefore, individuals appear to have unique inhibition-facilitation profiles that are relatively stable. Although the functional implications of individualized profiles are currently unknown, the relatively stable profiles may index underlying neural inhibition and excitation traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.