Evidence map›Paper›PMID 24245941›Full record

ReviewAnnual review of physiology2014

Live imaging of the lung.

Mark R Looney, Jahar Bhattacharya

Abstract readReview
In one paragraph

Review in Annual review of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Molecular mechanism of miRNA-23a in sepsis-induced lung injury.American journal of translational research · 2023
    Article
  7. Article
  8. Article
  9. MRSA-induced endothelial permeability and acute lung injury are attenuated by FTY720 S-phosphonate.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  10. Life (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Actually Seeing What Is Going on - Intravital Microscopy in Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021
    Review
  13. Review
  14. Article
  15. Review
  16. Tracing Antiviral CD8Journal of immunology (Baltimore, Md. : 1950) · 2019
    Review
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mark R LooneyDepartments of Medicine and Laboratory Medicine, University of California, San Francisco, California 94143; email: mark.looney@ucsf.edu.
Jahar Bhattacharya
Columbia University · USUniversity of California, San Francisco · US

Funding

SynthesisP30DK072517 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VERKMAN, ALAN S · 2005 to 2022
$18.1M
OPTICAL IMAGING OF MESENCHYMAL STEM CELL INTERACTIONS WITH LUNG MICROVESSELSR01HL057556 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI BHATTACHARYA, JAHAR · 1997 to 2020
$8.0M
MICROPUNCTURE STUDIES OF LUNG, WATER AND SOLUTE EXCHANGER01HL036024 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI BHATTACHARYA, JAHAR · 1985 to 2025
$7.0M
Platelet and megakaryocyte biology in the normal and injured lungR01HL107386 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOONEY, MARK ROBERTS · 2011 to 2020
$4.2M
OPTICAL IMAGING OF LUNG CAPILLARIES IN VIVOR01HL078645 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI BHATTACHARYA, JAHAR · 2004 to 2014
$3.1M
MICROPUNCTURE STUDIES OF LUNG WATER SOLUTE EXCHANGER37HL036024 · NHLBI · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI BHATTACHARYA, JAHAR · 1998 to 2007
$3.0M
NHLBI NIH HHS HL107386NHLBI NIH HHS HL36024NHLBI NIH HHS HL57556NHLBI NIH HHS HL78645NHLBI NIH HHS R01 HL036024NHLBI NIH HHS R01 HL057556NHLBI NIH HHS R01 HL078645NHLBI NIH HHS R01 HL107386NHLBI NIH HHS R37 HL036024NIDDK NIH HHS P30 DK072517
6 · The paper itself

Abstract

Live lung imaging has spanned the discovery of capillaries in the frog lung by Malpighi to the current use of single and multiphoton imaging of intravital and isolated perfused lung preparations incorporating fluorescent molecular probes and transgenic reporter mice. Along the way, much has been learned about the unique microcirculation of the lung, including immune cell migration and the mechanisms by which cells at the alveolar-capillary interface communicate with each other. In this review, we highlight live lung imaging techniques as applied to the role of mitochondria in lung immunity, mechanisms of signal transduction in lung compartments, studies on the composition of alveolar wall liquid, and neutrophil and platelet trafficking in the lung under homeostatic and inflammatory conditions. New applications of live lung imaging and the limitations of current techniques are discussed.

Indexed as

AnimalsBlood PlateletsBody FluidsDiagnostic ImagingGap JunctionsHumansIn Vitro TechniquesLungMicrocirculationMicroscopyMitochondriaNeutrophilsPulmonary AlveoliPulmonary Circulation

Identifiers

PMID24245941
PMCPMC4501380
OpenAlexW2972492663

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.