ArticleJournal of experimental & clinical cancer research : CR2013
Magnetic resonance imaging identifies early effects of sunitinib treatment in human melanoma xenografts.
Article in Journal of experimental & clinical cancer research : CR, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- RTK Inhibitors in Melanoma: From Bench to Bedside.Cancers · 2021Review
- Review
- Evaluation of Effects of TGF-β1 Inhibition on Gastric Cancer in Nude Mice by Diffusion Kurtosis Imaging and In-Line X-ray Phase Contrast Imaging With Sequential Histology.Journal of magnetic resonance imaging : JMRI · 2019Article
- Diffusion-Weighted MRI Is Insensitive to Changes in the Tumor Microenvironment Induced by Antiangiogenic Therapy.Translational oncology · 2018Article
- The effects of intravoxel contrast agent diffusion on the analysis of DCE-MRI data in realistic tissue domains.Magnetic resonance in medicine · 2018Article
- DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of Pancreatic Ductal Adenocarcinoma Xenografts.Neoplasia (New York, N.Y.) · 2018Article
- Increasing aggressiveness of patient-derived xenograft models of cervix carcinoma during serial transplantation.Oncotarget · 2018Article
- Article
- Vascular abnormalities and development of hypoxia in microscopic melanoma xenografts.Journal of translational medicine · 2017Article
- Antiangiogenic agents targeting different angiogenic pathways have opposite effects on tumor hypoxia in R-18 human melanoma xenografts.BMC cancer · 2017Article
- The Effect of Sunitinib Treatment in Human Melanoma Xenografts: Associations with Angiogenic Profiles.Translational oncology · 2017Article
- Three-dimensional Image-based Mechanical Modeling for Predicting the Response of Breast Cancer to Neoadjuvant Therapy.Computer methods in applied mechanics and engineering · 2017Article
- Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases.Clinical & experimental metastasis · 2017Article
- Improved sensitization effect of sunitinib in cancer cells of the esophagus under hypoxic microenviroment.Oncology letters · 2016Article
- Properdistatin inhibits angiogenesis and improves vascular function in human melanoma xenografts with low thrombospondin-1 expression.Oncotarget · 2016Article
- Diffusion-weighted and dynamic contrast-enhanced MRI of pancreatic adenocarcinoma xenografts: associations with tumor differentiation and collagen content.Journal of translational medicine · 2016Article
- Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases.Journal of experimental & clinical cancer research : CR · 2015Article
- Intravoxel Incoherent Motion Diffusion-weighted Magnetic Resonance Imaging for Monitoring the Early Response to ZD6474 from Nasopharyngeal Carcinoma in Nude Mouse.Scientific reports · 2015Article
- Early effects of low dose bevacizumab treatment assessed by magnetic resonance imaging.BMC cancer · 2015Article
- Correlation of tumor characteristics derived from DCE-MRI and DW-MRI with histology in murine models of breast cancer.NMR in biomedicine · 2015Article
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5 authors.
Funding
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Abstract
backgroundAntiangiogenic treatment may change the tumor microenvironment and hence influence the effect of conventional therapies. The potential of diffusion weighted magnetic resonance imaging (DW-MRI) and dynamic contrast enhanced MRI (DCE-MRI) in assessing microenvironmental effects of sunitinib treatment was investigated in this preclinical study.
methodsSunitinib-treated and untreated A-07 tumors were subjected to DW-MRI and DCE-MRI, and parametric images of ADC and Ktrans were produced. Microvascular density, hypoxic fraction, and necrotic fraction were assessed from immunohistochemical preparations, and tumor interstitial fluid pressure (IFP) was assessed with probe measurement.
resultsSunitinib-treated tumors showed reduced microvascular density, increased hypoxic fraction, increased necrotic fraction, increased ADC, and reduced Ktrans, but did not differ from untreated tumors in growth rate and IFP.
conclusionsSunitinib treatment affected the tumor microenvironment without affecting tumor size. DW-MRI and DCE-MRI were sensitive to the sunitinib-induced changes in the tumor microenvironment.
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