ArticleWorld journal of gastrointestinal pathophysiology2013
Genetic contribution to motility disorders of the upper gastrointestinal tract.
Article in World journal of gastrointestinal pathophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 19 citations in OpenAlex.
- Aerobic exercise improves gastrointestinal motility in psychiatric inpatients.World journal of gastroenterology · 2014Trial
- Focus on Achalasia in the Omics Era.International journal of molecular sciences · 2024Review
- Modern Achalasia: Diagnosis, Classification, and Treatment.Journal of neurogastroenterology and motility · 2023Review
- Effects of core strengthening exercise on colon transit time in young adult women.Journal of exercise science and fitness · 2021Article
- Genetic variants of immune-related genes IL17F and IL10 are associated with functional dyspepsia: A case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2017Article
- Functional dyspepsia: new insights into pathogenesis and therapy.The Korean journal of internal medicine · 2016Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motility disorders of the upper gastrointestinal tract encompass a wide range of different diseases. Esophageal achalasia and functional dyspepsia are representative disorders of impaired motility of the esophagus and stomach, respectively. In spite of their variable prevalence, what both diseases have in common is poor knowledge of their etiology and pathophysiology. There is some evidence showing that there is a genetic predisposition towards these diseases, especially for achalasia. Many authors have investigated the possible genes involved, stressing the autoimmune or the neurological hypothesis, but there is very little data available. Similarly, studies supporting a post-infective etiology, based on an altered immune response in susceptible individuals, need to be validated. Further association studies can help to explain this complex picture and find new therapeutic targets. The aim of this review is to summarize current knowledge of genetics in motility disorders of the upper gastrointestinal tract, addressing how genetics contributes to the development of achalasia and functional dyspepsia respectively.
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Registered trials
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