ReviewEplasty2013
Split rejection in vascularized composite allotransplantation.
Review in Eplasty, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01281267 (Transplantation of Allograft Face or Facial Subunit for Treatment of Severe Facial Deformation), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transplantation of Allograft Face or Facial Subunit for Treatment of Severe Facial Deformation
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Mortality and graft loss in face transplantation: lessons from two decades of experience.Clinical transplantation and research · 2026Review
- Donor adipose-derived stromal cells are vasoprotectant but unable to revert acute rejection in rodent vascularized composite allotransplants.Frontiers in immunology · 2025Article
- Immunohistochemical Analysis of Lymphocyte Populations in Acute Skin Rejection: The University Health Network Addition to the Banff Classification.Plastic and reconstructive surgery. Global open · 2023Article
- A chronic rejection model and potential biomarkers for vascularized composite allotransplantation.PloS one · 2020Article
- A Skin Rejection Grading System for Vascularized Composite Allotransplantation in a Preclinical Large Animal Model.Transplantation · 2019Article
- Composite tissue allotransplantation: opportunities and challenges.Cellular & molecular immunology · 2019Review
- Vascularized composite allotransplantation: current standards and novel approaches to prevent acute rejection and chronic allograft deterioration.Transplant international : official journal of the European Society for Organ Transplantation · 2016Review
- Current status of vascularized composite tissue allotransplantation.Burns & trauma · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionGraft monitoring following vascularized composite allotransplantation (VCA) relies primarily on serial skin biopsy. However, given that VCA comprised multiple tissue types, skin biopsy may not accurately reflect rejection in other transplanted tissue.
methodsA review of the literature on episodes of both acute and chronic rejection following VCA was completed. Special attention was given to how these patients were monitored for rejection and whether skin biopsy accurately reflected the state of other tissue types within VCA.
resultsFollowing VCA, skin biopsies accurately reflected episodes of acute rejection, but chronic rejection, resulting in both muscle fibrosis and graft vasculopathy, did not present with any ostensible skin changes.
conclusionVarious tissue types within VCA can reject at different times and rates. We define this phenomenon as "split rejection." Split rejection has significant implications on flap monitoring, as it suggests that skin biopsy alone may not be sufficient in monitoring long-term graft rejection.
Indexed as
Identifiers
24244785PMC3795428W15559101What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.