ArticlePloS one2013
ERK phosphorylation regulates sleep and plasticity in Drosophila.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
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- Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain.Journal of neurochemistry · 2023Review
- Many faces of sleep regulation: beyond the time of day and prior wake time.The FEBS journal · 2023Review
- Microglial TNFα orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep.The EMBO journal · 2023Article
- Control of circadian rhythm on cortical excitability and synaptic plasticity.Frontiers in neural circuits · 2023Review
- The interplay between macronutrients and sleep: focus on circadian and homeostatic processes.Frontiers in nutrition · 2023Review
- The role of calcium and CaMKII in sleep.Frontiers in systems neuroscience · 2022Review
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- Cucurbitacin B Suppresses Hyperglycemia Associated with a High Sugar Diet and Promotes Sleep inMolecules and cells · 2021Article
- Molecular Mechanisms of Memory Consolidation That Operate During Sleep.Frontiers in molecular neuroscience · 2021Review
- Phosphorylation Hypothesis of Sleep.Frontiers in psychology · 2020Review
- Short-Term Memory Deficits in the SLEEP Inbred Panel.Clocks & sleep · 2019Article
- Evolutionarily conserved regulation of sleep by epidermal growth factor receptor signaling.Science advances · 2019Article
- Astrocyte expression of the Drosophila TNF-alpha homologue, Eiger, regulates sleep in flies.PLoS genetics · 2018Article
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- Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila.Journal of neuroscience research · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Given the relationship between sleep and plasticity, we examined the role of Extracellular signal-regulated kinase (ERK) in regulating baseline sleep, and modulating the response to waking experience. Both sleep deprivation and social enrichment increase ERK phosphorylation in wild-type flies. The effects of both sleep deprivation and social enrichment on structural plasticity in the LNvs can be recapitulated by expressing an active version of ERK (UAS-ERK(SEM)) pan-neuronally in the adult fly using GeneSwitch (Gsw) Gsw-elav-GAL4. Conversely, disrupting ERK reduces sleep and prevents both the behavioral and structural plasticity normally induced by social enrichment. Finally, using transgenic flies carrying a cAMP response Element (CRE)-luciferase reporter we show that activating ERK enhances CRE-Luc activity while disrupting ERK reduces it. These data suggest that ERK phosphorylation is an important mediator in transducing waking experience into sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.