ArticlePloS one2013
Neuromodulation of olfactory sensitivity in the peripheral olfactory organs of the American cockroach, Periplaneta americana.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Unexpected Evolutionary Divergence of Tachykinin-Positive Neurons Innervating the Central Complex in Hexapods.The Journal of comparative neurology · 2026Article
- Article
- Aedes albopictus colonies from different geographic origins differ in their sleep and activity levels but not in the time of peak activity.Medical and veterinary entomology · 2024Article
- Rhythms in insect olfactory systems: underlying mechanisms and outstanding questions.The Journal of experimental biology · 2024Review
- The complex neurochemistry of the cockroach antennal heart.Cell and tissue research · 2024Article
- Article
- The relationships between microbiome diversity and epidemiology in domestic species of malaria-mediated mosquitoes of Korea.Scientific reports · 2023Article
- PaOctβ2R: Identification and Functional Characterization of an Octopamine Receptor Activating Adenylyl Cyclase Activity in the American CockroachInternational journal of molecular sciences · 2022Article
- Tachykinin signaling inhibits task-specific behavioral responsiveness in honeybee workers.eLife · 2021Article
- Bacterial-mediated RNAi and functional analysis of Natalisin in a moth.Scientific reports · 2021Article
- Transcriptomics supports local sensory regulation in the antenna of the kissing-bug Rhodnius prolixus.BMC genomics · 2020Article
- Characterization and its implication of a novel taste receptor detecting nutrients in the honey bee, Apis mellifera.Scientific reports · 2019Article
- Parasitoid Jewel Wasp Mounts Multipronged Neurochemical Attack to Hijack a Host Brain.Molecular & cellular proteomics : MCP · 2019Article
- Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic.Frontiers in neuroscience · 2019Review
- Characterization and Expression Profiling of Neuropeptides and G-Protein-Coupled Receptors (GPCRs) for Neuropeptides in the Asian Citrus Psyllid,International journal of molecular sciences · 2018Article
- Octopaminergic innervation and a neurohaemal release site in the antennal heart of the locust Schistocerca gregaria.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Biogenic Amines in Insect Antennae.Frontiers in systems neuroscience · 2017Review
- Leucokinin mimetic elicits aversive behavior in mosquito Aedes aegypti (L.) and inhibits the sugar taste neuron.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Ligand selectivity in tachykinin and natalisin neuropeptidergic systems of the honey bee parasitic mite Varroa destructor.Scientific reports · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Olfactory sensitivity exhibits daily fluctuations. Several studies have suggested that the olfactory system in insects is modulated by both biogenic amines and neuropeptides. However, molecular and neural mechanisms underlying olfactory modulation in the periphery remain unclear since neuronal circuits regulating olfactory sensitivity have not been identified. Here, we investigated the structure and function of these signaling pathways in the peripheral olfactory system of the American cockroach, Periplaneta americana, utilizing in situ hybridization, qRT-PCR, and electrophysiological approaches. We showed that tachykinin was co-localized with the octopamine receptor in antennal neurons located near the antennal nerves. In addition, the tachykinin receptor was found to be expressed in most of the olfactory receptor neurons in antennae. Functionally, the effects of direct injection of tachykinin peptides, dsRNAs of tachykinin, tachykinin receptors, and octopamine receptors provided further support for the view that both octopamine and tachykinin modulate olfactory sensitivity. Taken together, these findings demonstrated that octopamine and tachykinin in antennal neurons are olfactory regulators in the periphery. We propose here the hypothesis that octopamine released from neurons in the brain regulates the release of tachykinin from the octopamine receptor neurons in antennae, which in turn modulates the olfactory sensitivity of olfactory receptor neurons, which house tachykinin receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.