ArticlePloS one2013
Serotyping of Toxoplasma gondii in cats (Felis domesticus) reveals predominance of type II infections in Germany.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Toxoplasma gondii seroprevalence and risk factors of cats in the Budapest area.European journal of microbiology & immunology · 2024Article
- Toxoplasma gondii genotypes and frequency in domestic cats from Romania.BMC veterinary research · 2024Article
- A combination of GRA3, GRA6 and GRA7 peptides offer a useful tool for serotyping type II and IIIFrontiers in cellular and infection microbiology · 2024Article
- Serotyping, a challenging approach forFrontiers in medicine · 2023Review
- Development of a new serotyping ELISA for Toxoplasma gondii type II, type III and Africa 1 lineages using in silico peptide discovery methods, well categorized feline and human outbreak serum samples.BMC infectious diseases · 2022Article
- Biosensor Based Immunoassay: A New Approach for Serotyping ofNanomaterials (Basel, Switzerland) · 2021Article
- Genetic and histopathological characterization of Toxoplasma gondii genotypes isolated from free-range chickens reared in the metropolitan region of Rio de Janeiro state, Brazil.Parasitology research · 2021Article
- Article
- Toxoplasma gondii in small exotic felids from zoos in Europe and the Middle East: serological prevalence and risk factors.Parasites & vectors · 2019Article
- Seroprevalence and risk factors of Toxoplasma gondii among pregnant women in Adwa district, northern Ethiopia.BMC infectious diseases · 2019Article
- Serotyping ofFrontiers in cellular and infection microbiology · 2019Article
- Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii.Parasites & vectors · 2018Article
- Importance of serological cross-reactivity among Toxoplasma gondii, Hammondia spp., Neospora spp., Sarcocystis spp. and Besnoitia besnoiti.Parasitology · 2017Review
- Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection.Oncotarget · 2017Article
- Diagnosis of toxoplasmosis and typing of Toxoplasma gondii.Parasites & vectors · 2015Review
- Strain hypothesis of Toxoplasma gondii infection on the outcome of human diseases.Acta physiologica (Oxford, England) · 2015Review
- Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCats are definitive hosts of Toxoplasma gondii and play an essential role in the epidemiology of this parasite. The study aims at clarifying whether cats are able to develop specific antibodies against different clonal types of T. gondii and to determine by serotyping the T. gondii clonal types prevailing in cats as intermediate hosts in Germany. METHODOLOGY: To establish a peptide-microarray serotyping test, we identified 24 suitable peptides using serological T. gondii positive (n=21) and negative cat sera (n=52). To determine the clonal type-specific antibody response of cats in Germany, 86 field sera from T. gondii seropositive naturally infected cats were tested. In addition, we analyzed the antibody response in cats experimentally infected with non-canonical T. gondii types (n=7).
findingsPositive cat reference sera reacted predominantly with peptides harbouring amino acid sequences specific for the clonal T. gondii type the cats were infected with. When the array was applied to field sera from Germany, 98.8% (85/86) of naturally-infected cats recognized similar peptide patterns as T. gondii type II reference sera and showed the strongest reaction intensities with clonal type II-specific peptides. In addition, naturally infected cats recognized type II-specific peptides significantly more frequently than peptides of other type-specificities. Cats infected with non-canonical types showed the strongest reactivity with peptides presenting amino-acid sequences specific for both, type I and type III.
conclusionsCats are able to mount a clonal type-specific antibody response against T. gondii. Serotyping revealed for most seropositive field sera patterns resembling those observed after clonal type II-T. gondii infection. This finding is in accord with our previous results on the occurrence of T. gondii clonal types in oocysts shed by cats in Germany.
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