ArticlePloS one2013
Helicobacter pylori infection is associated with the presence of thyroid nodules in the euthyroid population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Association between Helicobacter pylori infection and thyroid dysfunction in adults visiting a tertiary care hospital in Karachi, Pakistan: a cross-sectional study.BMC endocrine disorders · 2026Article
- Recent advances in gut microbiota and thyroid disease: pathogenesis and therapeutics in autoimmune, neoplastic, and nodular conditions.Frontiers in cellular and infection microbiology · 2024Review
- The Correlation between Elevated HDL-Cholesterol, Body Mass Index, and Presence of Thyroid Nodules: A Retrospective Analysis.Journal of clinical medicine · 2023Article
- Article
- The association of uric acid with the development of thyroid nodules: a retrospective cohort study.BMC endocrine disorders · 2022Review
- Determining the Association Between Helicobacter pylori Infection and Treatment-Refractory Hypothyroidism.Cureus · 2022Article
- Sex-Specific Risk Factors Associated withInternational journal of general medicine · 2022Article
- Higher Prevalence of Non-thyroidal-Illness Syndrome in Elderly Male Patients With ActiveFrontiers in medicine · 2021Article
- Lack of Association BetweenFrontiers in cellular and infection microbiology · 2021Article
- The Effect of Inflammation on the Formation of Thyroid Nodules.International journal of endocrinology · 2020Article
- A Mechanism Exploration of Metabolic Syndrome Causing Nodular Thyroid Disease.International journal of endocrinology · 2019Article
- Meta-analysis of the correlation betweenOncotarget · 2017Article
- Effect of Non-Alcoholic Fatty Liver Disease on Estimated Glomerular Filtration Rate Could Be Dependent on Age.PloS one · 2015Article
- Beyond the stomach: an updated view of Helicobacter pylori pathogenesis, diagnosis, and treatment.World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori infection is associated with extragastric diseases. The thyroid may be one of the targets of chronic inflammation. Here, we sought to investigate whether H. pylori infections were associated with the presence of thyroid nodules. A total of 988 euthyroid subjects from China were included in this cross-sectional study. Four hundred thirty-five (44.0%) subjects were diagnosed as having thyroid nodules, and 486 (49.2%) were diagnosed with H. pylori infections. The thyroid nodules group had a higher proportion of H. pylori infections than the control group (P = 0.002). Free thyroxine (FT4) levels were lower and the prevalence of thyroid nodules was higher in patients with H. pylori infection compared to those without infection, even after adjustment for age, gender, and body mass index (BMI; all P < 0.05). The prevalence of H. pylori infection showed a decreasing trend as serum FT4 level increased (P(trend) = 0.020). Stepwise logistic regression analysis showed that H. pylori infection was significantly associated with the risk of thyroid nodules (odds ratio: 1.390, 95% confidence interval: 1.059-1.824, P = 0.018). Our results suggested that H. pylori infections were positively associated with the presence of thyroid nodules in the euthyroid population, whose thyroid functions were in the reference range.
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