ArticlePloS one2013
Inverse relationship of serum hepcidin levels with CD4 cell counts in HIV-infected patients selected from an Indonesian prospective cohort study.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Prevalence and risk factors of anemia among people living with HIV/AIDS in Southeast Asia: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Anemia, Iron Status, and HIV: A Systematic Review of the Evidence.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Can iron chelators ameliorate viral infections?Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Iron status among HIV-infected adults during the first year of antiretroviral therapy in Tanzania.HIV medicine · 2023Article
- Article
- Dysregulation of iron metabolism modulators in virologically suppressed HIV-infected patients.Frontiers in immunology · 2022Article
- Hematological parameters abnormalities and associated factors in HIV-positive adults before and after highly active antiretroviral treatment in Goba Referral Hospital, southeast Ethiopia: A cross-sectional study.SAGE open medicine · 2021Article
- A possible role for hepcidin in the detection of iron deficiency in severely anaemic HIV-infected patients in Malawi.PloS one · 2020Article
- High levels of serum IL-6 and serum hepcidin and low CD4 cell count were risk factors of anemia of chronic disease in HIV patients on the combination of antiretroviral therapy.HIV/AIDS (Auckland, N.Z.) · 2019Article
- Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages.Scientific reports · 2018Article
- The impact of antiretroviral therapy on iron homeostasis and inflammation markers in HIV-infected patients with mild anemia.Journal of translational medicine · 2017Article
- Serum hepcidin in infants born after 32 to 37 wk of gestational age.Pediatric research · 2016Observational
- Relationship Between Blood Concentrations of Hepcidin and Anemia Severity, Mycobacterial Burden, and Mortality Among Patients With HIV-Associated Tuberculosis.The Journal of infectious diseases · 2016Article
- HIV-Associated Tuberculosis: Does the Iron-Regulatory Hormone Hepcidin Connect Anemia With Poor Prognosis?The Journal of infectious diseases · 2016Article
- Pathophysiology of Iron Homeostasis during Inflammatory States.The Journal of pediatrics · 2015Review
- Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans.PLoS neglected tropical diseases · 2015Article
- Elevated Hepcidin Is Part of a Complex Relation That Links Mortality with Iron Homeostasis and Anemia in Men and Women with HIV Infection.The Journal of nutrition · 2015Article
- Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Coinfection with HIV-1 alleviates iron accumulation in patients with chronic hepatitis C virus infection.PloS one · 2014Article
- Iron, anemia and hepcidin in malaria.Frontiers in pharmacology · 2014Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDistortion of iron homeostasis may contribute to the pathogenesis of human immunodeficiency virus (HIV) infection and tuberculosis (TB). We studied the association of the central iron-regulatory hormone hepcidin with the severity of HIV and the association between hepcidin and other markers of iron homeostasis with development of TB.
methodsThree groups of patients were selected from a prospective cohort of HIV-infected subjects in Bandung, Indonesia. The first group consisted of HIV-infected patients who started TB treatment more than 30 days after cohort enrollment (cases). The second group consisted of HIV-infected patients who were matched for age, gender and CD4 cell count to the cases group (matched controls). The third group consisted of HIV-infected patients with CD4 cell counts above 200 cells/mm(3) (unmatched controls). Iron parameters including hepcidin were compared using samples collected at cohort enrollment, and compared with recently published reference values for serum hepcidin.
resultsA total of 127 HIV-infected patients were included, 42 cases together with 42 matched controls and 43 unmatched controls. Patients with advanced HIV infection had elevated serum hepcidin and ferritin levels. Hepcidin levels correlated inversely with CD4 cells and hemoglobin. Cases had significantly higher hepcidin and ferritin concentrations at cohort enrollment compared to matched controls, but these differences were fully accounted for by the cases who started TB treatment between day 31 and 60 after enrollment. Hepcidin levels were not different in those with or without hepatitis C infection.
conclusionIron metabolism is distorted in advanced HIV infection with CD4 cell counts correlating inversely with serum hepcidin levels. High serum hepcidin levels and hyperferritinemia were found in patients starting TB treatment shortly after cohort enrollment, suggesting that these parameters have a predictive value for development of manifest TB in HIV-infected patients.
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