ArticlePloS one2013
Association of a body mass index genetic risk score with growth throughout childhood and adolescence.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Interactions between Polygenic Risk of Obesity and Dietary Factors on Anthropometric Outcomes: A Systematic Review and Meta-Analysis of Observational Studies.The Journal of nutrition · 2024Pooled it
- Age at adiposity rebound and the relevance for obesity: a systematic review and meta-analysis.International journal of obesity (2005) · 2022Pooled it
- GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.Science advances · 2019Pooled it
- A genome-wide association study of body mass index across early life and childhood.International journal of epidemiology · 2015Pooled it
- Child temperament predicts the adiposity rebound. A 9-year prospective sibling control study.PloS one · 2018Trial
- Early-Life Factors and Body Mass Index Trajectories Among Children in the ECHO Cohort.JAMA network open · 2025Article
- A framework for conducting GWAS using repeated measures data with an application to childhood BMI.Nature communications · 2024Article
- A framework for conducting time-varying genome-wide association studies: An application to body mass index across childhood in six multiethnic cohorts.medRxiv : the preprint server for health sciences · 2024Article
- The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study.American journal of human genetics · 2022Article
- Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight.Human molecular genetics · 2022Article
- Birthweight associations with parental obesity: retrospective analysis of 1,778 singleton term births following assisted reproductive treatment.F&S reports · 2021Article
- Longitudinal association of a body mass index (BMI) genetic risk score with growth and BMI changes across the life course: The Cardiovascular Risk in Young Finns Study.International journal of obesity (2005) · 2020Article
- Exclusive breastfeeding can attenuate body-mass-index increase among genetically susceptible children: A longitudinal study from the ALSPAC cohort.PLoS genetics · 2020Article
- Maternal BMI-Increasing Genetic Risk Score and Fetal Weights among Diverse US Ethnic Groups.Obesity (Silver Spring, Md.) · 2019Article
- Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts.Obesity (Silver Spring, Md.) · 2019Article
- Shared genetic underpinnings of childhood obesity and adult cardiometabolic diseases.Human genomics · 2019Article
- Individual and shared effects of social environment and polygenic risk scores on adolescent body mass index.Scientific reports · 2018Article
- Associations between genetic variants associated with body mass index and trajectories of body fatness across the life course: a longitudinal analysis.International journal of epidemiology · 2018Article
- Article
- Genetic risk score for adult body mass index associations with childhood and adolescent weight gain in an African population.Genes & nutrition · 2018Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundWhile the number of established genetic variants associated with adult body mass index (BMI) is growing, the relationships between these variants and growth during childhood are yet to be fully characterised. We examined the association between validated adult BMI associated single nucleotide polymorphisms (SNPs) and growth trajectories across childhood. We investigated the timing of onset of the genetic effect and whether it was sex specific.
methodsChildren from the ALSPAC and Raine birth cohorts were used for analysis (n = 9,328). Genotype data from 32 adult BMI associated SNPs were investigated individually and as an allelic score. Linear mixed effects models with smoothing splines were used for longitudinal modelling of the growth parameters and measures of adiposity peak and rebound were derived.
resultsThe allelic score was associated with BMI growth throughout childhood, explaining 0.58% of the total variance in BMI in females and 0.44% in males. The allelic score was associated with higher BMI at the adiposity peak (females = 0.0163 kg/m(2) per allele, males = 0.0123 kg/m(2) per allele) and earlier age (-0.0362 years per allele in males and females) and higher BMI (0.0332 kg/m(2) per allele in females and 0.0364 kg/m(2) per allele in males) at the adiposity rebound. No gene:sex interactions were detected for BMI growth.
conclusionsThis study suggests that known adult genetic determinants of BMI have observable effects on growth from early childhood, and is consistent with the hypothesis that genetic determinants of adult susceptibility to obesity act from early childhood and develop over the life course.
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