ArticlePloS one2013
Reduction of thromboembolic events in meningioma surgery: a cohort study of 724 consecutive patients.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Thromboembolic prophylaxis in neurosurgical practice: a systematic review.Acta neurochirurgica · 2023Pooled it
- Adverse events in meningioma surgery classified using the therapy-disability-neurology (TDN) grading system.Journal of neuro-oncology · 2025Article
- Risk factors for postoperative thrombotic complications after meningioma resection: a retrospective single-center study in China.Frontiers in neurology · 2025Article
- Venous Compromise/Deep Venous Thrombosis During Parasagittal Meningiomas Resection.Acta neurochirurgica. Supplement · 2025Article
- Impact of Perioperative Acetylsalicylic Acid (ASA) Administration on Postoperative Intracranial Hemorrhage (pICH) and Thromboembolic Events in Patients with Intracranial Meningiomas.Journal of clinical medicine · 2024Article
- Optimizing patient outcome in intracranial tumor surgery: a detailed prospective study of adverse events and mortality reduction strategies in neurosurgery.Acta neurochirurgica · 2024Article
- Factors related to morbidity and mortality of meningiomas resection‑associated venous thromboembolism (Review).Molecular and clinical oncology · 2023Review
- Meningioma resection and venous thromboembolism incidence, management, and outcomes.Research and practice in thrombosis and haemostasis · 2023Article
- Venous thromboembolic and hemorrhagic events after meningioma surgery: A single-center retrospective cohort study of risk factors.PloS one · 2022Article
- Systemic coagulation is activated in patients with meningioma and glioblastoma.Journal of neuro-oncology · 2021Article
- Preoperative risk factors associated with new focal neurological deficit and other major adverse events in first-time intracranial meningioma neurosurgery.Acta neurochirurgica · 2021Article
- The interhemispheric fissure-surgical outcome of interhemispheric approaches.Neurosurgical review · 2021Article
- Papillary meningioma: a rare cause of massive supratentorial intracerebral hemorrhage.Journal of surgical case reports · 2020Article
- Perioperative anticoagulation in patients with intracranial meningioma: No increased risk of intracranial hemorrhage?PloS one · 2020Article
- Post-operative cardiovascular complications and time to recurrence in meningioma patients treated with versus without pre-operative embolization: a retrospective cohort study of 741 patients.Journal of neuro-oncology · 2018Article
- Risk of post-operative venous thromboembolism in patients with meningioma.Journal of neuro-oncology · 2018Article
- Impact of operative length on post-operative complications in meningioma surgery: a NSQIP analysis.Journal of neuro-oncology · 2017Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeningiomas are associated with the highest postoperative rate of venous thromboembolic events (VTE) among all intracranial tumors. The aim of this study is to compare two entirely different VTE prophylaxis regimens in 724 consecutive patients undergoing meningioma surgery.
methodsTwo cohorts at a single institution treated with different regimens to prevent VTE were reviewed retrospectively. Cohort A (n = 482; 314 females, mean age 57 years, range: 11-87 years) received our institutional regimen during the years 1999-2006, consisting of low-molecular-weight heparin (LMWH) and compression stockings. For cohort B (n = 242; 163 females, mean age 56.8 years, range: 16-90 years), during the years 2008-2010, the management included intraoperative 10°-20° leg elevation with intermittent pneumatic compression (IPC), heparin and LMWH administration. We compared the incidence of the endpoints pulmonary embolism (PE), deep venous thrombosis (DVT), hemorrhage and death, taking into account several known associated risk factors.
resultsFor all endpoints, we observed a more favorable outcome with the new regimen. The difference in incidence of PEs (cohort A: 38/482, 8%; cohort B: 6/242, 2.5%) reached statistical significance (p = 0.002). In general, patients with skull base meningiomas had a higher risk for PE (OR 2.77). Regarding VTE prophylaxis, an adjusted subgroup analysis suggests that the new regimen is particularly beneficial for patients with skull base meningiomas.
conclusionsWe recommend perioperative prophylaxis using a management composed of intraoperative leg-elevation, IPC, early heparin administration and LMWH to reduce the risk for PE.
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