Trial reportPloS one2013
Orthostatic change in blood pressure and incidence of atrial fibrillation: results from a bi-ethnic population based study.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03924388 (The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Spinal Cord Stimulation on Autonomic Function in People With Spinal Cord Injury
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Orthostatic hypotension and the risk of atrial fibrillation and other cardiovascular diseases: An updated meta-analysis of prospective cohort studies.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- Orthostatic hypotension is associated with new-onset atrial fibrillation: Systemic review and meta-analysis.Indian heart journalPooled it
- Risk of Orthostatic Hypotension in Chronic Kidney Disease: A Community-Based Cohort Study.Kidney & blood pressure research · 2025Article
- Role of Orthostatic Hypotension in the Development of Dementia in People With and Without Cardiovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Clinical Epidemiology of Systolic and Diastolic Orthostatic Hypotension in Patients on Peritoneal Dialysis.Journal of clinical medicine · 2021Article
- Resting Heart Rate, Short-Term Heart Rate Variability and Incident Atrial Fibrillation (from the Multi-Ethnic Study of Atherosclerosis (MESA)).The American journal of cardiology · 2019Article
- [Prevalence and relations of orthostatic hypotension in patients 80 years old and over from a primary care unit].Atencion primaria · 2019Observational
- Relation of Orthostatic Hypotension With New-Onset Atrial Fibrillation (From the Framingham Heart Study).The American journal of cardiology · 2018Article
- Autonomic dysfunction is associated with cardiac remodelling in heart failure patients.ESC heart failure · 2018Article
- Cardiac Autonomic Dysfunction and Incidence of Atrial Fibrillation: Results From 20 Years Follow-Up.Journal of the American College of Cardiology · 2017Article
- Orthostatic Hypotension and Risk of Venous Thromboembolism in 2 Cohort Studies.American journal of hypertension · 2016Article
- Orthostatic Hypotension and Mortality in Elderly Frail Patients: A Retrospective Cross-Sectional Study.Medicine · 2015Article
- The "Road" to Atrial Fibrillation: The Role of the Cardiac Autonomic Nervous System.Journal of atrial fibrillationArticle
- Orthostatic Hypertension and Hypotension and Outcomes in CKD: The CRIC (Chronic Renal Insufficiency Cohort) Study.Kidney medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAutonomic fluctuations are associated with the initiation and possibly maintenance of atrial fibrillation (AF). However, little is known about the relationship between orthostatic blood pressure change, a common manifestation of autonomic dysfunction, and incident AF.
methodsWe examined whether supine-to-standing changes in systolic blood pressure (SBP) are associated with incident AF in 12,071 African American and white men and women aged 45-64 years, enrolled in the Atherosclerosis Risks in Communities (ARIC) study. Orthostatic hypotension (OH) was defined as a supine-standing drop in SBP by ≥20 mmHg or diastolic blood pressure by ≥10 mmHg. AF cases were identified based on study scheduled 12-lead ECG, hospital discharge ICD codes, and death certificates through 2009.
resultsOH was seen in 603 (5%) at baseline. During an average follow-up of 18.1 years, 1438 (11.9%) study participants developed AF. Incident AF occurred more commonly among those with OH than those without, a rate of 9.3 vs. 6.3 per 1000 person years, (p<0.001). The age, gender, and race adjusted hazard ratio (95%CI) of AF among those with OH compared to those without was 1.62 (1.34, 2.14). This association was attenuated after adjustment for common AF risk factors to HR 1.40 (1.15, 1.71), a strength similar to that of diabetes or hypertension with AF in the same model. A non-linear relationship between orthostatic change in SBP and incident AF was present after multivariable adjustment.
conclusionsOH is associated with higher AF incidence. Whether interventions that decrease OH can reduce AF risk remains unknown.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.