Trial reportPloS one2013
Bimanual force coordination in Parkinson's disease patients with bilateral subthalamic deep brain stimulation.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Parkinson's disease impairs grip force release during a sinusoidal force tracking task.Experimental brain research · 2026Article
- Subthalamic nucleus in patients with Parkinson's disease encodes changes and magnitude of applied force.NPJ Parkinson's disease · 2026Article
- Advances in Neurorehabilitation: Strategies and Outcomes for Traumatic Brain Injury Recovery.Cureus · 2024Review
- Upper extremity asymmetry due to nerve injuries or central neurologic conditions: a scoping review.Journal of neuroengineering and rehabilitation · 2023Article
- Systemic effects of deep brain stimulation on synergic control in Parkinson's disease.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2018Article
- Subthalamic Neurons Encode Both Single- and Multi-Limb Movements in Parkinson's Disease Patients.Scientific reports · 2017Article
- Impaired Object Handling during Bimanual Task Performance in Multiple Sclerosis.Multiple sclerosis international · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveStudies of bimanual actions similar to activities of daily living (ADLs) are currently lacking in evaluating fine motor control in Parkinson's disease patients implanted with bilateral subthalamic deep brain stimulators. We investigated basic time and force characteristics of a bimanual task that resembles performance of ADLs in a group of bilateral subthalamic deep brain stimulation (DBS) patients.
methodsPatients were evaluated in three different DBS parameter conditions off stimulation, on clinically derived stimulation parameters, and on settings derived from a patient-specific computational model. Model-based parameters were computed as a means to minimize spread of current to non-motor regions of the subthalamic nucleus via Cicerone Deep Brain Stimulation software. Patients were evaluated off parkinsonian medications in each stimulation condition.
resultsThe data indicate that DBS parameter state does not affect most aspects of fine motor control in ADL-like tasks; however, features such as increased grip force and grip symmetry varied with the stimulation state. In the absence of DBS parameters, patients exhibited significant grip force asymmetry. Overall UPDRS-III and UPDRS-III scores associated with hand function were lower while patients were experiencing clinically-derived or model-based parameters, as compared to the off-stimulation condition.
conclusionWhile bilateral subthalamic DBS has been shown to alleviate gross motor dysfunction, our results indicate that DBS may not provide the same magnitude of benefit to fine motor coordination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.