ArticlePloS one2013
Bone sparing effect of a novel phytoestrogen diarylheptanoid from Curcuma comosa Roxb. in ovariectomized rats.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 41 citations in OpenAlex.
- DPHD fromACS omega · 2026Article
- Fermented soybean powder containing S-equol alleviates the postmenopausal signs of ovariectomized rats.Food science and biotechnology · 2025Article
- In Vitro and In Vivo Bone-Forming Effect of a Low-Molecular-Weight Collagen Peptide.Journal of microbiology and biotechnology · 2024Article
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- Effects of GW1929 on uterus, ovary and bone metabolism function in perimenopause rats.American journal of translational research · 2020Article
- Syntheses and antibacterial activities of 4 linear nonphenolic diarylheptanoids.Turkish journal of chemistry · 2020Article
- Water extract of Cnidii Rhizoma suppresses RANKL-induced osteoclastogenesis in RAW 264.7 cell by inhibiting NFATc1/c-Fos signaling and prevents ovariectomized bone loss in SD-rat.BMC complementary and alternative medicine · 2019Article
- Protective effect of Glycyrrhiza glabra roots extract on bone mineral density of ovariectomized rats.BioMedicine · 2019Article
- Beneficial Role of Hydro-alcoholic Seed Extract ofEthiopian journal of health sciences · 2018Article
- Liraglutide exerts a bone-protective effect in ovariectomized rats with streptozotocin-induced diabetes by inhibiting osteoclastogenesis.Experimental and therapeutic medicine · 2018Article
- A Comparative Study ofBioMed research international · 2017Article
- Danshen enhanced the estrogenic effects of Qing E formula in ovariectomized rats.BMC complementary and alternative medicine · 2016Article
- The Protective Effects of Alisol A 24-Acetate from Alisma canaliculatum on Ovariectomy Induced Bone Loss in Vivo.Molecules (Basel, Switzerland) · 2016Article
- Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis) on the Ovariectomized Mice.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Effect of (-)-epigallocatechin-3-gallate in preventing bone loss in ovariectomized rats and possible mechanisms.International journal of clinical and experimental medicine · 2014Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytoestrogens have been implicated in the prevention of bone loss in postmenopausal osteoporosis. Recently, an active phytoestrogen from Curcuma comosa Roxb, diarylheptanoid (DPHD), (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol, was found to strongly promote human osteoblast function in vitro. In the present study, we demonstrated the protective effect of DPHD on ovariectomy-induced bone loss (OVX) in adult female Sprague-Dawley rats with 17β-estradiol (E2, 10 µg/kg Bw) as a positive control. Treatment of OVX animals with DPHD at 25, 50, and 100 mg/kg Bw for 12 weeks markedly increased bone mineral density (BMD) of tibial metaphysis as measured by peripheral Quantitative Computed Tomography (pQCT). Histomorphometric analysis of bone structure indicated that DPHD treatment retarded the ovariectomy-induced deterioration of bone microstructure. Ovariectomy resulted in a marked decrease in trabecular bone volume, number and thickness and these changes were inhibited by DPHD treatment, similar to that seen with E2. Moreover, DPHD decreased markers of bone turnover, including osteocalcin and tartrate resistant acid phosphatase (TRAP) activity. These results suggest that DPHD has a bone sparing effect in ovariectomy-induced trabecular bone loss and prevents deterioration of bone microarchitecture by suppressing the rate of bone turnover. Therefore, DPHD appears to be a promising candidate for preserving bone mass and structure in the estrogen deficient women with a potential role in reducing postmenopausal osteoporosis.
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