ArticlePloS one2013
Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Photobiomodulation for Parkinson's Disease in Animal Models: A Systematic Review.Biomolecules · 2020Pooled it
- Alterations in energy production in aFrontiers in aging neuroscience · 2026Article
- Optimizing Photobiomodulation Radiometric and Spectral Parameters In Vitro to Enhance Angiogenesis and Mitochondrial Function.International journal of molecular sciences · 2024Article
- Photobiomodulation for Neurodegenerative Diseases: A Scoping Review.International journal of molecular sciences · 2024Article
- Parkinson's Disease and Photobiomodulation: Potential for Treatment.Journal of personalized medicine · 2024Review
- Remote photobiomodulation targeted at the abdomen or legs provides effective neuroprotection against parkinsonian MPTP insult.The European journal of neuroscience · 2023Article
- The Chicken Embryo Chorioallantoic Membrane as an In Vivo Model for Photodynamic Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Review
- The effect of photobiomodulation on the brain during wakefulness and sleep.Frontiers in neuroscience · 2022Review
- Neurodegenerative Disorders: Spotlight on Sphingolipids.International journal of molecular sciences · 2021Review
- Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Current application and future directions of photobiomodulation in central nervous diseases.Neural regeneration research · 2021Review
- The Importance ofCells · 2021Review
- Inhibiting Mitochondrial CytochromeFrontiers in physiology · 2021Article
- Mitochondrial Dysfunction and Parkinson's Disease-Near-Infrared Photobiomodulation as a Potential Therapeutic Strategy.Frontiers in aging neuroscience · 2020Review
- Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends.Biomedical engineering letters · 2019Review
- Brain Photobiomodulation Therapy: a Narrative Review.Molecular neurobiology · 2018Review
- Photobiomodulation-induced changes in a monkey model of Parkinson's disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum.Experimental brain research · 2017Article
- Cardiolipin promotes electron transport between ubiquinone and complex I to rescueThe Journal of cell biology · 2017Article
- Article
- Photobiomodulation Suppresses Alpha-Synuclein-Induced Toxicity in an AAV-Based Rat Genetic Model of Parkinson's Disease.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial electron transport chain (ETC) defects are observed in Parkinson's disease (PD) patients and in PD fly- and mouse-models; however it remains to be tested if acute improvement of ETC function alleviates PD-relevant defects. We tested the hypothesis that 808 nm infrared light that effectively penetrates tissues rescues pink1 mutants. We show that irradiating isolated fly or mouse mitochondria with 808 nm light that is absorbed by ETC-Complex IV acutely improves Complex IV-dependent oxygen consumption and ATP production, a feature that is wavelength-specific. Irradiating Drosophila pink1 mutants using a single dose of 808 nm light results in a rescue of major systemic and mitochondrial defects. Time-course experiments indicate mitochondrial membrane potential defects are rescued prior to mitochondrial morphological defects, also in dopaminergic neurons, suggesting mitochondrial functional defects precede mitochondrial swelling. Thus, our data indicate that improvement of mitochondrial function using infrared light stimulation is a viable strategy to alleviate pink1-related defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.