Trial reportPloS one2013
High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010.
Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Environmental Metals and Cardiovascular Disease in Adults: A Systematic Review Beyond Lead and Cadmium.Current environmental health reports · 2016Pooled it
- Spectrophotometric determination of trace-amount tungsten in environmental and biological samplesRSC advances · 2026Article
- Relationship and distribution patterns between geochemical backgrounds of W and MScientific reports · 2026Article
- The effects of tungsten inhalation and continuous administration of angiotensin II on cardiac injury and pulmonary outcomes.Toxicology and applied pharmacology · 2026Article
- Association of metal and metalloid exposure with cardiovascular-kidney-metabolic syndrome: mediation by inflammation, oxidative stress, and aging.BMC public health · 2025Article
- Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis.Journal of the American College of Cardiology · 2024Article
- Impact of the environmental pollution on cardiovascular diseases: From epidemiological to molecular evidence.Heliyon · 2024Review
- Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis (MESA).medRxiv : the preprint server for health sciences · 2023Article
- Acute inhalation of tungsten particles results in early signs of cardiac injury.Toxicology letters · 2023Article
- Development and application of an evidence-based directed acyclic graph to evaluate the associations between metal mixtures and cardiometabolic outcomes.Epidemiologic methods · 2023Article
- Tungsten toxicity and carcinogenesis.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Overview of the cardiovascular effects of environmental metals: New preclinical and clinical insights.Toxicology and applied pharmacology · 2022Article
- Hydrocalumite as well as the Formation of Scheelite Induced by Its Dissolution, Removing Aqueous Tungsten with Varying Concentrations.International journal of environmental research and public health · 2022Article
- Efficient and Fast Removal of Aqueous Tungstate by an Iron-Based LDH Delaminated in L-Asparagine.International journal of environmental research and public health · 2022Article
- Multipollutant, longitudinal analysis of the association between urinary tungsten and incident diabetes in a rural population.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- An atlas of metallome and metabolome interactions and associations with incident diabetes in the Strong Heart Family Study.Environment international · 2021Article
- Tungsten Accumulation in Hot Spring Sediments Resulting from Preferred Sorption of Aqueous Polytungstates to Goethite.International journal of environmental research and public health · 2021Article
- Urine tungsten and chronic kidney disease in rural Colorado.Environmental research · 2021Article
- Environmental heavy metals and cardiovascular diseases: Status and future direction.Chronic diseases and translational medicine · 2020Review
- The association of urine metals and metal mixtures with cardiovascular incidence in an adult population from Spain: the Hortega Follow-Up Study.International journal of epidemiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn recent years there has been an exponential increase in tungsten demand, potentially increasing human exposure to the metal. Currently, the toxicology of tungsten is poorly understood, but mounting evidence suggests that both the elemental metal and its alloys have cytotoxic effects. Here, we investigate the association between tungsten and cardiovascular disease (CVD) or stroke using six waves of the National Health and Nutrition Examination Survey (NHANES).
methodsWe investigated associations using crude and adjusted logistic regression models in a cohort of 8614 adults (18-74 years) with 193 reported stroke diagnoses and 428 reported diagnoses of CVD. We also stratified our data to characterize associations in a subset of younger individuals (18-50 years).
resultsElevated tungsten concentrations were strongly associated with an increase in the prevalence of stroke, independent of typical risk factors (Odds Ratio (OR): 1.66, 95% Confidence Interval (95% CI): 1.17, 2.34). The association between tungsten and stroke in the young age category was still evident (OR: 2.17, 95% CI: 1.33, 3.53).
conclusionThis study represents the most comprehensive analysis of the human health effects of tungsten to date. Individuals with higher urinary tungsten concentrations have double the odds of reported stroke. We hypothesize that the pathological pathway resulting from tungsten exposure may involve oxidative stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.