ArticlePLoS genetics2013
A genetic approach to the recruitment of PRC2 at the HoxD locus.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation.Nature genetics · 2026Article
- The impact of cell states on heterochromatin dynamics.The Biochemical journal · 2024Review
- Nucleation and spreading maintain Polycomb domains every cell cycle.Cell reports · 2024Article
- Review
- Dynamic Competition of Polycomb and Trithorax in Transcriptional Programming.Annual review of biochemistry · 2020Review
- Mitotic Inheritance of PRC2-Mediated Silencing: Mechanistic Insights and Developmental Perspectives.Frontiers in plant science · 2020Review
- Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects.Epigenetics & chromatin · 2019Article
- Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes.BMC biology · 2019Article
- Towards understanding of PRC2 binding to RNA.RNA biology · 2019Review
- The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases.Epigenomes · 2019Article
- Three classes of response elements for human PRC2 and MLL1/2-Trithorax complexes.Nucleic acids research · 2018Article
- PTE, a novel module to target Polycomb Repressive Complex 1 to the human cyclin D2 (The Journal of biological chemistry · 2018Article
- Capturing the Onset of PRC2-Mediated Repressive Domain Formation.Molecular cell · 2018Article
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- Formation of a Polycomb-Domain in the Absence of Strong Polycomb Response Elements.PLoS genetics · 2016Article
- Review
- Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.Acta neuropathologica · 2015Article
- Overexpression of HOX genes is prevalent in Ewing sarcoma and is associated with altered epigenetic regulation of developmental transcription programs.Epigenetics · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycomb group (PcG) proteins are essential for the repression of key factors during early development. In Drosophila, the polycomb repressive complexes (PRC) associate with defined polycomb response DNA elements (PREs). In mammals, however, the mechanisms underlying polycomb recruitment at targeted loci are poorly understood. We have used an in vivo approach to identify DNA sequences of importance for the proper recruitment of polycomb proteins at the HoxD locus. We report that various genomic re-arrangements of the gene cluster do not strongly affect PRC2 recruitment and that relatively small polycomb interacting sequences appear necessary and sufficient to confer polycomb recognition and targeting to ectopic loci. In addition, a high GC content, while not sufficient to recruit PRC2, may help its local spreading. We discuss the importance of PRC2 recruitment over Hox gene clusters in embryonic stem cells, for their subsequent coordinated transcriptional activation during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.