ArticlePLoS computational biology2013
Synaptic plasticity in neural networks needs homeostasis with a fast rate detector.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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Who cites it
81 citing papers in PubMed.
- Disorder-mediated non-equilibrium photocurrent redistribution enables homeostatic synaptic conditioning in AgBiSNature communications · 2026Article
- NeuroPlast: a learnable activation function evaluated under knowledge distillation for medical image classification.Frontiers in artificial intelligence · 2026Article
- β-Adrenergic Receptor Activation Modulates the Induction of Complex Spike-Dependent LTP by Regulating Multiple Forms of Heterosynaptic Plasticity.Hippocampus · 2025Article
- Churning Better Transcranial Direct Current Stimulation Outcome with Accelerated Protocols: Understanding the Non-linear Dynamics through Metaplasticity.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Review
- Resource-dependent heterosynaptic spike-timing-dependent plasticity in recurrent networks with and without synaptic degeneration.Frontiers in computational neuroscience · 2025Article
- Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Structural influences on synaptic plasticity: The role of presynaptic connectivity in the emergence of E/I co-tuning.PLoS computational biology · 2024Article
- Plasticity of Response Properties of Mouse Visual Cortex Neurons Induced by Optogenetic Tetanization In Vivo.Current issues in molecular biology · 2024Article
- Learning what matters: Synaptic plasticity with invariance to second-order input correlations.PLoS computational biology · 2024Article
- A dynamic attractor network model of memory formation, reinforcement and forgetting.PLoS computational biology · 2023Article
- Long- and short-term history effects in a spiking network model of statistical learning.Scientific reports · 2023Article
- Intrinsic neural diversity quenches the dynamic volatility of neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules.Molecular and cellular neurosciences · 2023Review
- Dendrites help mitigate the plasticity-stability dilemma.Scientific reports · 2023Article
- Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs.eLife · 2022Article
- Stability and learning in excitatory synapses by nonlinear inhibitory plasticity.PLoS computational biology · 2022Article
- Behavioral Timescale Cooperativity and Competitive Synaptic Interactions Regulate the Induction of Complex Spike Burst-Dependent Long-Term Potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson's Disease Pathophysiology.Frontiers in network physiology · 2022Review
- Article
- Network-centered homeostasis through inhibition maintains hippocampal spatial map and cortical circuit function.Cell reports · 2021Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Hebbian changes of excitatory synapses are driven by and further enhance correlations between pre- and postsynaptic activities. Hence, Hebbian plasticity forms a positive feedback loop that can lead to instability in simulated neural networks. To keep activity at healthy, low levels, plasticity must therefore incorporate homeostatic control mechanisms. We find in numerical simulations of recurrent networks with a realistic triplet-based spike-timing-dependent plasticity rule (triplet STDP) that homeostasis has to detect rate changes on a timescale of seconds to minutes to keep the activity stable. We confirm this result in a generic mean-field formulation of network activity and homeostatic plasticity. Our results strongly suggest the existence of a homeostatic regulatory mechanism that reacts to firing rate changes on the order of seconds to minutes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.