ArticleJournal of immunology (Baltimore, Md. : 1950)2013
Cutting edge: The signals for the generation of T cell memory are qualitatively different depending on TCR ligand strength.
Article in Journal of immunology (Baltimore, Md. : 1950), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- CD39 Is Expressed on Functional Effector and Tissue-resident Memory CD8+ T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- STING controls T cell memory fitness during infection through T cell-intrinsic and IDO-dependent mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The perception and response of T cells to a changing environment are based on the law of initial value.Science signaling · 2022Review
- Interplay of Inflammatory, Antigen and Tissue-Derived Signals in the Development of Resident CD8 Memory T Cells.Frontiers in immunology · 2021Review
- T-cell receptor affinity in the age of cancer immunotherapy.Molecular carcinogenesis · 2020Review
- Altered Binding of Tumor Antigenic Peptides to MHC Class I Affects CD8Cancer immunology research · 2018Article
- Identification of Human B-1 Helper T Cells With a Th1-Like Memory Phenotype and High Integrin CD49d Expression.Frontiers in immunology · 2018Article
- Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8Frontiers in immunology · 2018Review
- Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells.Scientific reports · 2017Article
- NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Innate and virtual memory T cells in man.European journal of immunology · 2015Article
- The tyrosine kinase Itk suppresses CD8+ memory T cell development in response to bacterial infection.Scientific reports · 2015Article
- TCR Signaling in T Cell Memory.Frontiers in immunology · 2015Review
- T cell-NF-κB activation is required for tumor control in vivo.Journal for immunotherapy of cancer · 2015Article
- Innate memory T cells.Advances in immunology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal strength is altered. To gain further insight into this question, we used a TCRβ transmembrane domain mutant model that is defective in the generation of memory in response to high-affinity ligands. Surprisingly, lowering TCR signal strength, by stimulation with low-affinity ligands, resulted in normal memory development. Restoration of memory correlated with recovery of TCR-dependent NF-κB signaling. Thus, these data provide novel evidence that the requirements for memory are qualitatively different depending on TCR signal strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.