ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2014
Genome-wide significant localization for working and spatial memory: Identifying genes for psychosis using models of cognition.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Genetic landscape of adult executive function reveals a cell-type-specific developmental origin.Nature communications · 2026Pooled it
- Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory.Scientific reports · 2025Article
- Identification of novel protective loci for executive function using the trail making test part B in the Long Life Family Study.bioRxiv : the preprint server for biology · 2025Article
- The contribution of copy number variants to psychiatric symptoms and cognitive ability.Molecular psychiatry · 2023Review
- Cocktail-party listening and cognitive abilities show strong pleiotropy.Frontiers in neurology · 2023Article
- Genetic influences on externalizing psychopathology overlap with cognitive functioning and show developmental variation.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Behavioral-genetic associations in the Human Connectome Project.Experimental brain research · 2020Article
- Minimal Relationship between Local Gyrification and General Cognitive Ability in Humans.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Brain function during stages of working memory in schizophrenia and psychotic bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Clinical correlates of subsyndromal depression in African American individuals with psychosis: The relationship with positive symptoms and comorbid substance dependence.Schizophrenia research · 2019Article
- A QTL on chromosome 3q23 influences processing speed in humans.Genes, brain, and behavior · 2019Article
- Genetic contributions to Trail Making Test performance in UK Biobank.Molecular psychiatry · 2018Article
- Cognitive genomics: Searching for the genetic roots of neuropsychological functioning.Neuropsychology · 2017Review
- The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk.European psychiatry : the journal of the Association of European Psychiatrists · 2017Article
- Serum phosphatidylinositol as a biomarker for bipolar disorder liability.Bipolar disorders · 2017Article
- Absence of population structure across elevational gradients despite large phenotypic variation in mountain chickadees (Royal Society open science · 2017Article
- The genetic basis of the comorbidity between cannabis use and major depression.Addiction (Abingdon, England) · 2017Article
- Disrupted Working Memory Circuitry in Adolescent Psychosis.Frontiers in human neuroscience · 2017Article
- Genome-wide significant loci for addiction and anxiety.European psychiatry : the journal of the Association of European Psychiatrists · 2016Article
- Genome-Wide Analyses of Working-Memory Ability: A Review.Current behavioral neuroscience reports · 2014Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
Abstract
It is well established that risk for developing psychosis is largely mediated by the influence of genes, but identifying precisely which genes underlie that risk has been problematic. Focusing on endophenotypes, rather than illness risk, is one solution to this problem. Impaired cognition is a well-established endophenotype of psychosis. Here we aimed to characterize the genetic architecture of cognition using phenotypically detailed models as opposed to relying on general IQ or individual neuropsychological measures. In so doing we hoped to identify genes that mediate cognitive ability, which might also contribute to psychosis risk. Hierarchical factor models of genetically clustered cognitive traits were subjected to linkage analysis followed by QTL region-specific association analyses in a sample of 1,269 Mexican American individuals from extended pedigrees. We identified four genome wide significant QTLs, two for working and two for spatial memory, and a number of plausible and interesting candidate genes. The creation of detailed models of cognition seemingly enhanced the power to detect genetic effects on cognition and provided a number of possible candidate genes for psychosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.