ArticleAge (Dordrecht, Netherlands)2014
Exercise-training-induced changes in metabolic capacity with age: the role of central cardiovascular plasticity.
Article in Age (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05343611 (Combining Vitamin E-functionalized CHOcolate With Physical Exercise to Reduce the risK Of Protein Energy Malnutrition in Pre-dementia AGEd People), which is not on this map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combining Vitamin E-functionalized CHOcolate With Physical Exercise to Reduce the risK Of Protein Energy Malnutrition in Pre-dementia AGEd People
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Programming Interval Training to Optimize Time-Trial Performance: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- The Effect of Exercise Training on the Energetic Cost of Cycling.Sports medicine (Auckland, N.Z.) · 2015Pooled it
- Aerobic high-intensity interval training and maximal strength training in patients with unspecific musculoskeletal disorders improve V̇OEuropean journal of sport science · 2024Trial
- Aerobic high-intensity intervals are superior to improve V̇OScandinavian journal of medicine & science in sports · 2023Trial
- Maximal strength training in patients with inflammatory rheumatic disease: implications for physical function and quality of life.European journal of applied physiology · 2022Trial
- Smartphone-Assisted High-Intensity Interval Training in Inflammatory Rheumatic Disease Patients: Randomized Controlled Trial.JMIR mHealth and uHealth · 2021Trial
- High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes.European journal of applied physiology · 2017Trial
- The effect of exercise training on the course of cardiac troponin T and I levels: three independent training studies.Scientific reports · 2015Trial
- High-intensity interval training in patients with substance use disorder.BioMed research international · 2014Trial
- A stochastic, physiology-based digital twin model of hemostasis and oxygenation in trauma resuscitation.Research square · 2026Article
- Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults.The Journal of physiology · 2026Article
- Cardiorespiratory fitness in working adults undergoing rehabilitation: the role of lifestyle and body composition- a cross-sectional study.Frontiers in physiology · 2026Article
- Plasticity of the heart in response to changes in physical activity.The Journal of physiology · 2025Review
- Muscle oxygen consumption and microvascular function in healthy aging assessed by near-infrared spectroscopy: effect of adipose tissue thickness and physical fitness.Frontiers in physiology · 2025Article
- Aging increases metabolic capacity and reduces work efficiency during handgrip exercise in males.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Effect of Exercise Training on Arterial Stiffness in Overweight or Obese Populations.International journal of sports medicine · 2022Article
- Extreme duration exercise affects old and younger men differently.Acta physiologica (Oxford, England) · 2022Article
- Complex lifestyle intervention among inactive older adults with elevated cardiovascular disease risk and obesity: a mixed-method, single-arm feasibility study for RESTART-a randomized controlled trial.Pilot and feasibility studies · 2021Article
- Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology.Frontiers in physiology · 2021Review
- Effect of Aerobic Exercise Training and Deconditioning on Oxidative Capacity and Muscle Mitochondrial Enzyme Machinery in Young and Elderly Individuals.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Although aging is typically associated with a decline in maximal oxygen consumption (VO2max), young and old subjects, of similar initial muscle metabolic capacity, increased quadriceps VO2max equally when this small muscle mass was trained in isolation. As it is unclear if this preserved exercise-induced plasticity with age is still evident with centrally challenging whole body exercise, we assessed maximal exercise responses in 13 young (24 ± 2 years) and 13 old (60 ± 3 years) males, matched for cycling VO2max (3.82 ± 0.66 and 3.69 ± 0.30 L min(-1), respectively), both before and after 8 weeks of high aerobic intensity cycle exercise training. As a consequence of the training both young and old significantly improved VO2max (13 ± 6 vs. 6 ± 7 %) and maximal power output (20 ± 6 vs. 10 ± 6 %, respectively) from baseline, however, the young exhibited a significantly larger increase than the old. Similarly, independently assessed maximal cardiac output (Q max) tended to increase more in the young (16 ± 14 %) than in the old (11 ± 12 %), with no change in a-vO2 difference in either group. Further examination of the components of Q max provided additional evidence of reduced exercise-induced plasticity in both maximal heart rate (young -3 %, old 0 %) and stroke volume (young 19 ± 15, old 11 ± 11 %) in the old. In combination, these findings imply that limited central cardiovascular plasticity may be responsible, at least in part, for the attenuated response to whole body exercise training with increasing age.
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