ArticleMagnetic resonance in medicine2014
N-acetyl-aspartyl-glutamate detection in the human brain at 7 Tesla by echo time optimization and improved Wiener filtering.
Article in Magnetic resonance in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Multinuclear Magnetic Resonance Spectroscopy at Ultra-High-Field: Assessing Human Cerebral Metabolism in Healthy and Diseased States.Metabolites · 2023Review
- MRSCloud: A cloud-based MRS tool for basis set simulation.Magnetic resonance in medicine · 2022Article
- Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: aTranslational psychiatry · 2022Article
- Effects of carrier frequency mismatch on frequency-selective spectral editing.Magma (New York, N.Y.) · 2019Article
- Simultaneous measurement of glutamate, glutamine, GABA, and glutathione by spectral editing without subtraction.Magnetic resonance in medicine · 2018Article
- Fitting interrelated datasets: metabolite diffusion and general lineshapes.Magma (New York, N.Y.) · 2017Article
- Fast computation of full density matrix of multispin systems for spatially localized in vivo magnetic resonance spectroscopy.Medical physics · 2017Article
- Evaluating metabolites in patients with major depressive disorder who received mindfulness-based cognitive therapy and healthy controls using short echo MRSI at 7 Tesla.Magma (New York, N.Y.) · 2016Article
- Reliability of 7T (1) H-MRS measured human prefrontal cortex glutamate, glutamine, and glutathione signals using an adapted echo time optimized PRESS sequence: A between- and within-sessions investigation.Journal of magnetic resonance imaging : JMRI · 2016Article
- Spectral fitting using basis set modified by measured B0 field distribution.NMR in biomedicine · 2015Article
- Measurement of regional variation of GABA in the human brain by optimized point-resolved spectroscopy at 7 T in vivo.NMR in biomedicine · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo report enhanced signal detection for measuring N-acetyl-aspartyl-glutamate (NAAG) in the human brain at 7 Tesla by echo time (TE) -optimized point-resolved spectroscopy (PRESS) and improved Wiener filtering.
methodsUsing a highly efficient in-house developed numerical simulation program, a PRESS sequence with (TE1 , TE2 ) = (26, 72) ms was found to maximize the NAAG signals relative to the overlapping Glu signals. A new Wiener filtering water reference deconvolution method was developed to reduce broadening and distortions of metabolite peaks caused by B0 inhomogeneity and eddy currents.
resultsMonte Carlo simulation results demonstrated that the new Wiener filtering method offered higher spectral resolution, reduced spectral artifacts, and higher accuracy in NAAG quantification compared with the original Wiener filtering method. In vivo spectra and point spread functions of signal distortion confirmed that the new Wiener filtering method lead to improved spectral resolution and reduced spectral artifacts.
conclusionTE-optimized PRESS in combination with a new Wiener filtering method made it possible to fully use both the NAAG singlet signal at 2.05 ppm and the NAAG multiplet signal at 2.18 ppm in the quantification of NAAG. A more accurate characterization of lineshape distortion for Wiener filtering needs B0 field maps and segmented anatomical images to exclude contribution from cerebral spinal fluid.
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