ArticleJournal of molecular neuroscience : MN2014
The CRHR1 gene contributes to genetic susceptibility of aggressive behavior towards others in Chinese southwest Han population.
Article in Journal of molecular neuroscience : MN, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Pooled it
- Forensic Value of Genetic Variants Associated with Anti-Social Behavior.Diagnostics (Basel, Switzerland) · 2021Review
- Glucocorticoid receptor gene (NR3C1) is hypermethylated in adult males with aggressive behaviour.International journal of legal medicine · 2021Article
- Two Novel SNPs in the PLCL2 Gene Associated with Large Artery Atherosclerotic Stroke Identified by Fine-Mapping.Journal of molecular neuroscience : MN · 2020Article
- Association of Corticotropin-Releasing Hormone Receptor-1 Gene Polymorphisms and Personality Traits with Violent Aggression in Male Adolescents.Journal of molecular neuroscience : MN · 2020Article
- Article
- Associations of rs3740677 within GAB2 Gene with LOAD in Chinese Han Population.Molecular neurobiology · 2017Article
- Association of lipid metabolism relevant gene FBXW7 polymorphism with coronary artery disease in Uygur Chinese population in Xinjiang, China: a case-control.International journal of clinical and experimental pathology · 2017Article
- Article
- The role of hypothalamus-pituitary-adrenal genes and childhood trauma in borderline personality disorder.European archives of psychiatry and clinical neuroscience · 2016Article
- Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population.PloS one · 2015Article
- Comparison of Genetic Variants in Cancer-Related Genes between Chinese Hui and Han Populations.PloS one · 2015Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence suggests that the hypothalamic-pituitary-adrenal (HPA) axis might play a major role in genetic susceptibility of aggressive behavior. The aim of the present study is to investigate the association between corticotrophin-releasing hormone receptor 1 (CRHR1) gene and aggressive behavior in Chinese southwest Han population. Participants consist of 282 healthy controls and 177 violent criminals (including robbery and intentional injury, which represent for aggressive behavior towards property and aggressive behavior towards others). Three tag single nucleotide polymorphisms (SNPs) of CRHR1 gene including rs4458044, rs242924, and rs1768996 were genotyped using improved multiplex ligase detection reaction (iMLDR) methods. Single-locus analysis revealed that none of the studied SNPs was significantly associated with the risk of aggressive behavior; however, haplotype analysis showed that a haplotype GGA significantly increased the susceptibility of aggressive behavior towards others with an odds ratios equal to 3.32 (p = 0.003). The present results, for the first time, indicate that the CRHR1 gene polymorphism is significantly associated with aggressive behavior in Chinese southwest Han population. Subjects with GGA haplotype have an increased susceptibility to aggressive behavior towards others.
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