ArticleInflammopharmacology2014
Analgesic and antiinflammatory activities of the ethyl acetate fraction of Bidens pilosa (Asteraceae).
Article in Inflammopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Exploring the phytochemical profile, antioxidant and anti-inflammatory potential ofFrontiers in pharmacology · 2025Pooled it
- Potential Relevance ofDrug design, development and therapy · 2026Review
- Differences in responses of invasive and native plants to climate change: a case study ofFrontiers in plant science · 2025Article
- Ethnomedical knowledge of plants used in alternative medicine to treat hemorrhoidal diseases in Lubumbashi, Haut-Katanga province, Southern Democratic Republic of Congo.BMC complementary medicine and therapies · 2024Article
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- AMolecules (Basel, Switzerland) · 2023Article
- Immunomodulatory Properties of Natural Extracts and Compounds Derived fromPharmaceutics · 2023Review
- Anti-inflammatory potential of dichloromethane leaf extracts ofAfrican health sciences · 2021Article
- Acetonic Fraction ofFrontiers in veterinary science · 2019Article
- Medicinal Plants Used in the Treatment of Mental and Neurological Disorders in Ghana.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Pharmacological potential of Bidens pilosa L. and determination of bioactive compounds using UHPLC-QqQBMC complementary and alternative medicine · 2017Article
- Bidens pilosa Ethylene acetate extract can protect against L-NAME-induced hypertension on rats.BMC complementary and alternative medicine · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bidens pilosa is an Asteraceae widely used in traditional medicine for the treatment of various ailments including pain and inflammation. The present work was undertaken to assess the analgesic and antiinflammatory properties of the ethyl acetate fraction of methylene chloride/methanol (1:1) extract of leaves of Bidens pilosa at the gradual doses of 50, 100 and 200 mg/kg in mice and rats, respectively. The analgesic properties of Bidens pilosa were investigated using the acetic acid writhing, hot plate, capsaicin and formalin-induced pain models. This was followed by a study of the antiinflammatory properties using carrageenan, dextran, histamine and serotonin to induce acute inflammation in rat hind paw. The extract provided a significant (p < 0.01) reduction in pain induced by all four models of nociception. It also presented significant (p < 0.05) antiinflammatory activity in all four models of acute inflammation. These results show that the ethyl acetate fraction of methylene chloride/methanol (1:1) of Bidens pilosa has both analgesic and antiinflammatory properties. The qualitative analysis of the fraction by the high-performance liquid chromatography (HPLC) fingerprint revealed the presence of two flavonoids, namely quercetin and iso-okanin, known to have antiinflammatory and antinociceptive properties, which could be responsible for the analgesic and antiinflammatory effects observed.
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