Evidence map›Paper›PMID 24242825›Full record

ArticleAmerican journal of hypertension2014

Acute effects of a mixed meal on arterial stiffness and central hemodynamics in healthy adults.

Jennifer L Taylor, Timothy B Curry, Luke J Matzek, Michael J Joyner, Darren P Casey

Open access · bronzeAbstract read
In one paragraph

Article in American journal of hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Hemodynamics and Arterial Stiffness in Response to Oral Glucose Loading in Individuals with Type II Diabetes and Controlled Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023
    Article
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  14. Review
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  17. Influence of sympathetic nerve activity on aortic hemodynamics and pulse wave velocity in women.American journal of physiology. Heart and circulatory physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jennifer L TaylorDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota.
Timothy B Curry
Luke J Matzek
Michael J Joyner
Darren P Casey
Mayo Clinic · US

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CROW, SCOTT J · 1995 to 2015
$17.0M
Impact of Aging on Skeletal Muscle Blood Flow Kinetics During ExerciseR00HL105467 · NHLBI · UNIVERSITY OF IOWA · PI CASEY, DARREN PATRICK · 2013 to 2015
$726k
Sympathetic activation: a link ot the metabolic syndromeK23DK082424 · NIDDK · MAYO CLINIC ROCHESTER · PI CURRY, TIMOTHY BRIAN · 2008 to 2011
$621k
Impact of Aging on Skeletal Muscle Blood Flow Kinetics During ExerciseK99HL105467 · NHLBI · MAYO CLINIC ROCHESTER · PI CASEY, DARREN PATRICK · 2011 to 2012
$171k
NCRR NIH HHS UL1 RR024150NHLBI NIH HHS HL105467NHLBI NIH HHS K99 HL105467NHLBI NIH HHS R00 HL105467NIDDK NIH HHS K23 DK082424NIDDK NIH HHS K23 DK82424NIDDK NIH HHS P30 DK050456NIDDK NIH HHS P30 DK50456
6 · The paper itself

Abstract

backgroundElevated central pressures and arterial stiffness are associated with increased peripheral resistance and higher sympathetic nervous system activity. Additionally, consumption of a meal is known to be sympathoexcitatory. However, the acute effects of a meal on aortic wave reflection and stiffness are unknown. Therefore, we tested the hypothesis that aortic wave reflection and stiffness would increase after a meal.

methodsWe examined these effects using high-fidelity radial arterial pressure waveforms and carotid-femoral pulse wave velocity measured noninvasively by applanation tonometry before and 60 and 180 minutes after ingestion of a liquid mixed meal (Ensure; 40% of daily energy expenditure) in 17 healthy adults (9 men/8 women; aged 29 ± 2 years). Additionally, we measured sympathetic activity by microneurography at baseline and up to 60 minutes after the meal.

resultsAlthough sympathetic activity increased after the meal, both peripheral and central pressures were reduced at 180 minutes from baseline (all P < 0.05). Contrary to our hypothesis, augmentation index (14% ± 3% vs. 2% ± 3% vs. 8% ± 3%), augmentation index normalized for heart rate (8% ± 3% vs. -3% ± 3% vs. 3% ± 3%), augmented pressure (5 ± 1 mm Hg vs. 1 ± 1 mm Hg vs. 3 ± 1 mm Hg), and pulse wave velocity (7.1 ± 0.2 m/s vs. 6.7 ± 0.2 m/s vs. 6.7 ± 0.1 m/s) were substantially reduced at 60 and 180 minutes after the meal (all P < 0.05).

conclusionsTaken together, our results suggest that a liquid mixed meal acutely decreases central hemodynamics and arterial stiffness in healthy adults, which may be a result of meal-related increases in insulin and/or visceral vasodilation.

Indexed as

EatingHemodynamicsMealsVascular StiffnessAdultBlood PressureFemaleHealthy VolunteersHeart RateHumansMaleManometryPostprandial PeriodPulse Wave AnalysisSympathetic Nervous SystemTime Factorsaortic pressureblood pressurehypertensionmixed mealpulse wave velocitysympathetic nerve activitywave reflection.

Identifiers

PMID24242825
PMCPMC3915744
OpenAlexW2165507888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.