ArticleLearning & memory (Cold Spring Harbor, N.Y.)2013
Inactivation of medial prefrontal cortex or acute stress impairs odor span in rats.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Secondary Somatosensory Cortex Is Required for Learning but Not Execution of a Tactile Discrimination.The European journal of neuroscience · 2026Article
- Activity of CaMKII-expressing neurons in medial prefrontal cortex of male and female Long-Evans rats is necessary for encoding odor information and novelty recognition in an odor-based incidental memory test.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- High-THCeNeuro · 2023Article
- Social Odour Perception and Stress Responses in Women's Quality of Partner Relationship and Attachment Style.Behavioral sciences (Basel, Switzerland) · 2023Article
- Male and female impairments in odor span are observed in a rat model of PTSD.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands.Neuroscience and biobehavioral reviews · 2022Review
- Smell and Stress Response in the Brain: Review of the Connection between Chemistry and Neuropharmacology.Molecules (Basel, Switzerland) · 2021Review
- Roles of the medial prefrontal cortex, mediodorsal thalamus, and their combined circuit for performance of the odor span task in rats: analysis of memory capacity and foraging behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Childhood stress, grown-up brain networks: corticolimbic correlates of threat-related early life stress and adult stress response.Psychological medicine · 2018Article
- Effects of N-Methyl-D-aspartate (NMDA) antagonists ketamine, methoxetamine, and phencyclidine on the odor span test of working memory in rats.Experimental and clinical psychopharmacology · 2018Article
- Validation of the human odor span task: effects of nicotine.Psychopharmacology · 2017Article
- Interactions between medial prefrontal cortex and dorsomedial striatum are necessary for odor span capacity in rats: role of GluN2B-containing NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Medial prefrontal cortex and dorsomedial striatum are necessary for the trial-unique, delayed nonmatching-to-location (TUNL) task in rats: role of NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Behavioral pharmacology of the odor span task: Effects of flunitrazepam, ketamine, methamphetamine and methylphenidate.Journal of the experimental analysis of behavior · 2016Article
- Olfactory Stimulus Control and the Behavioral Pharmacology of Remembering.Behavior analysis (Washington, D.C.) · 2016Article
- Influence of pharmacological manipulations of NMDA and cholinergic receptors on working versus reference memory in a dual component odor span task.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies.Neuroscience and biobehavioral reviews · 2015Review
- Behavioral flexibility in rats and mice: contributions of distinct frontocortical regions.Genes, brain, and behavior · 2015Review
- Prefrontal cortical GABA modulation of spatial reference and working memory.The international journal of neuropsychopharmacology · 2014Article
- GluN2B-containing NMDA receptors and AMPA receptors in medial prefrontal cortex are necessary for odor span in rats.Frontiers in behavioral neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The capacity of working memory is limited and is altered in brain disorders including schizophrenia. In rodent working memory tasks, capacity is typically not measured (at least not explicitly). One task that does measure working memory capacity is the odor span task (OST) developed by Dudchenko and colleagues. In separate experiments, the effects of medial prefrontal cortex (mPFC) inactivation or acute stress on the OST were assessed in rats. Inactivation of the mPFC profoundly impaired odor span without affecting olfactory sensitivity. Acute stress also significantly reduced odor span. These findings support a potential role of the OST in developing novel therapeutics for disorders characterized by impaired working memory capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.