Evidence map›Paper›PMID 24241693›Full record

ArticleNature immunology2014

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.

Melanie Wencker, Gleb Turchinovich, Rafael Di Marco Barros, Livija Deban, Anett Jandke, Andrew Cope, Adrian C Hayday

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed
9.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 212 citations in OpenAlex.

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  9. Innateness transcriptome gradients characterize mouse T lymphocyte populations.Journal of immunology (Baltimore, Md. : 1950) · 2025
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  17. Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024
    Review
  18. Review
  19. γδ T cell antigen receptor polyspecificity enables T cell responses to a broad range of immune challenges.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Melanie Wencker1] London Research Institute, Cancer Research UK, London, UK. [2] Peter Gorer Department of Immunobiology, King's College London, London, UK. [3] These authors contributed equally to this work.
Gleb Turchinovich1] London Research Institute, Cancer Research UK, London, UK. [2] Peter Gorer Department of Immunobiology, King's College London, London, UK. [3] Present address: Department of Biomedicine, University of Basel, Basel, Switzerland. [4] These authors contributed equally to this work.
Rafael Di Marco Barros1] London Research Institute, Cancer Research UK, London, UK. [2] University College London, London, UK.
Livija DebanLondon Research Institute, Cancer Research UK, London, UK.
Anett JandkeLondon Research Institute, Cancer Research UK, London, UK.
Andrew CopeCentre for the Molecular and Cell Biology of Inflammation, King's College London, London, UK.
Adrian C Hayday1] London Research Institute, Cancer Research UK, London, UK. [2] Peter Gorer Department of Immunobiology, King's College London, London, UK.
Cancer Research UK · GBKing's College London · GB

Funding

Cancer Research UK 19309Wellcome Trust
6 · The paper itself

Abstract

The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity. In studies that explain how such cells can straddle innate and adaptive immunity, we found that signaling via antigen receptors, whose conventional role is to facilitate clonal T cell activation, was critical for the development of innate-like T cells but then was rapidly attenuated, which accommodated the cells' innate responsiveness. These findings permitted the identification of a previously unknown innate-like T cell subset and indicate that T cell hyporesponsiveness, a state traditionally linked to tolerance, may be fundamental to T cells entering the innate compartment and thereby providing lymphoid stress surveillance.

Indexed as

Adaptive ImmunityAnimalsAnimals, NewbornCells, CulturedFlow CytometryGreen Fluorescent ProteinsImmunity, InnateInterleukin-17MiceMice, Inbred BALB CMice, Inbred C57BLMice, TransgenicNuclear Receptor Subfamily 4, Group A, Member 1Receptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaSignal TransductionGreen Fluorescent ProteinsInterleukin-17Nuclear Receptor Subfamily 4, Group A, Member 1Receptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaZap70 protein, mouseZAP-70 Protein-Tyrosine Kinase

Identifiers

PMID24241693
PMCPMC6485477
OpenAlexW2093670317

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.