ArticleJAMA2013
Trends in aortic valve replacement for elderly patients in the United States, 1999-2011.
Article in JAMA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03084510 (REPRISE China), which is not on this map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
REPRISE China: REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of Lotus Edge™ Valve System - Clinical Evaluation in China
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- The early and long-term outcomes of coronary artery bypass grafting added to aortic valve replacement compared to isolated aortic valve replacement in elderly patients: a systematic review and meta-analysis.Heart and vessels · 2022Pooled it
- Safety and Use of Anticoagulation After Aortic Valve Replacement With Bioprostheses: A Meta-Analysis.Circulation. Cardiovascular quality and outcomes · 2016Pooled it
- Effectiveness of early cardiac rehabilitation in patients with heart valve surgery: a randomized, controlled trial.The Journal of international medical research · 2022Trial
- Safety, effectiveness and haemodynamic performance of a new stented aortic valve bioprosthesis.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2017Trial
- Trial
- Contemporary Review of Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement with Concomitant Mitral Stenosis.Current cardiology reviews · 2026Review
- Initial surgery versus conservative management of chronic severe aortic regurgitation in mild symptomatic older patients.International journal of cardiology. Heart & vasculature · 2025Article
- Article
- Racial/Ethnic Disparities in Aortic Valve Replacement Among Medicare Beneficiaries in the United States, 2012-2019.The American journal of medicine · 2024Article
- Effect of Sex and Flow Status on Outcomes After Surgical or Transcatheter Aortic Valve Replacement.JACC. Advances · 2024Article
- Administrative Model for Profiling Hospital Performance on Coronary Artery Bypass Graft Surgery: Based on the Chinese Hospital Quality Monitoring System.Journal of the American Heart Association · 2024Article
- Racial, Ethnic, and Gender Disparities in Valvular Heart Failure Management.Heart failure clinics · 2023Review
- Aortic Stenosis and Outcomes in Patients With Atrial Fibrillation: A Nationwide Cohort Study.Journal of the American Heart Association · 2023Article
- Did ethno-racial disparities in access to transcatheter aortic valve replacement change over time?JTCVS open · 2022Article
- Different calcification patterns of tricuspid and bicuspid aortic valves and their clinical impact.Interactive cardiovascular and thoracic surgery · 2022Article
- Sex differences in aortic stenosis: Identification of knowledge gaps for sex-specific personalized medicine.American heart journal plus : cardiology research and practice · 2022Article
- Distribution, Characteristics, and Management of Older Patients With Valvular Heart Disease in China: China-DVD Study.JACC. Asia · 2022Article
- Defining value in cardiac surgery: A contemporary analysis of cost variation across the United States.JTCVS open · 2022Article
- Effect of malnutrition and frailty status on surgical aortic valve replacement.General thoracic and cardiovascular surgery · 2022Article
- Impact of Non-Valvular Non-Coronary Concomitant Procedures on Outcomes of Surgical Aortic Valve Replacement in Intermediate Risk Patients.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
importanceThere is a need to describe contemporary outcomes of surgical aortic valve replacement (AVR) as the population ages and transcatheter options emerge.
objectiveTo assess procedure rates and outcomes of surgical AVR over time. DESIGN, SETTING, AND
participantsA serial cross-sectional cohort study of 82,755,924 Medicare fee-for-service beneficiaries undergoing AVR in the United States between 1999 and 2011. MAIN OUTCOMES AND MEASURES: Procedure rates for surgical AVR alone and with coronary artery bypass graft (CABG) surgery, 30-day and 1-year mortality, and 30-day readmission rates.
resultsThe AVR procedure rate increased by 19 (95% CI, 19-20) procedures per 100,000 person-years over the 12-year period (P<.001), with an age-, sex-, and race-adjusted rate increase of 1.6% (95% CI, 1.0%-1.8%) per year. Mortality decreased at 30 days (absolute decrease, 3.4%; 95% CI, 3.0%-3.8%; adjusted annual decrease, 4.1%; 95% CI, 3.7%- 4.4%) per year and at 1 year (absolute decrease, 2.6%; 95% CI, 2.1%-3.2%; adjusted annual decrease, 2.5%; 95% CI, 2.3%-2.8%). Thirty-day all-cause readmission also decreased by 1.1% (95% CI, 0.9%-1.3%) per year. Aortic valve replacement with CABG surgery decreased, women and black patients had lower procedure and higher mortality rates, and mechanical prosethetic implants decreased, but 23.9% of patients 85 years and older continued to receive a mechanical prosthesis in 2011. CONCLUSIONS AND RELEVANCE: Between 1999 and 2011, the rate of surgical AVR for elderly patients in the United States increased and outcomes improved substantially. Medicare data preclude the identification of the causes of the findings and the trends in procedure rates and outcomes cannot be causally linked. Nevertheless, the findings may be a useful benchmark for outcomes with surgical AVR for older patients eligible for surgery considering newer transcatheter treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.