ArticleEuropean journal of nutrition2014
Diversity of oat varieties in eliciting the early inflammatory events in celiac disease.
Article in European journal of nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Oat Intake and Risk of Type 2 Diabetes, Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Effect of additional water supply during grain filling on protein composition and epitope characteristics of winter oats.Current research in food science · 2022Article
- Commercial oats in gluten-free diet: A persistent risk for celiac patients.Frontiers in nutrition · 2022Article
- Pigmented Corn Varieties as Functional Ingredients for Gluten-Free Products.Foods (Basel, Switzerland) · 2021Article
- A Novel Sprouted Oat Fermented Beverage: Evaluation of Safety and Health Benefits for Celiac Individuals.Nutrients · 2021Article
- Review
- Ancient and Modern Cereals as Ingredients of the Gluten-Free Diet: Are They Safe Enough for Celiac Consumers?Foods (Basel, Switzerland) · 2021Review
- Investigation of Protein and Epitope Characteristics of Oats and Its Implications for Celiac Disease.Frontiers in nutrition · 2021Article
- Review
- Oats as a Safe Alternative to Triticeae Cereals for People Suffering from Celiac Disease? A Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Review
- Mediterranean Gluten-Free Diet: Is It a Fair Bet for the Treatment of Gluten-Related Disorders?Frontiers in nutrition · 2020Review
- Article
- Gluten Immunogenic Peptides as Standard for the Evaluation of Potential Harmful Prolamin Content in Food and Human Specimen.Nutrients · 2018Review
- Perspective: Gluten-Free Products for Patients with Celiac Disease Should Not Contain Trace Levels.Advances in nutrition (Bethesda, Md.) · 2017Article
- Characterization of celiac disease related oat proteins: bases for the development of high quality oat varieties suitable for celiac patients.Scientific reports · 2017Article
- Why Oats Are Safe and Healthy for Celiac Disease Patients.Medical sciences (Basel, Switzerland) · 2016Review
- Celiac Disease and Gluten-Free Oats: A Canadian Position Based on a Literature Review.Canadian journal of gastroenterology & hepatology · 2016Review
- Pure Oats as Part of the Canadian Gluten-Free Diet in Celiac Disease: The Need to Revisit the Issue.Canadian journal of gastroenterology & hepatology · 2016Review
- Identification and molecular characterization of oat peptides implicated on coeliac immune response.Food & nutrition research · 2016Article
- Role of oats in celiac disease.World journal of gastroenterology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCeliac disease (CD) is an autoimmune enteropathy, triggered by dietary gluten. The only treatment is a strict gluten-free diet. Oats are included in the list of gluten-free ingredients by European Regulation, but the safety of oats in CD is still a matter of debate. The present study examined the capability of different oat cultivars of activating the gliadin-induced transglutaminase-2 (TG2)-dependent events in some in vitro models of CD. In addition, we compared this capability with the electrophoresis pattern of peptic-tryptic digests of the proteins of the oat cultivars.
methodsK562(S) cells agglutination, transepithelial electrical resistance of T84-cell monolayers, intracellular levels of TG2 and phosphorylated form of protein 42-44 in T84 cells were the early gliadin-dependent events studied.
resultsThe results showed that the Nave oat cultivar elicited these events, whereas Irina and Potenza varieties did not. The ability of a cultivar to activate the above-described events was associated with the electrophoretic pattern of oat proteins and their reactivity to anti-gliadin antibodies.
conclusionWe found significant differences among oat cultivars in eliciting the TG2-mediated events of CD inflammation. Therefore, the safety of an oat cultivar in CD might be screened in vitro by means of biochemical and biological assays, before starting a clinical trial to definitely assess its safety.
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