ArticleJournal of epidemiology2014
Diagnostic accuracy of the E-plate serum antibody test kit in detecting Helicobacter pylori infection among Japanese children.
Article in Journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood.Pediatrics international : official journal of the Japan Pediatric Society · 2020Guideline
- Non-invasive diagnostic tests for Helicobacter pylori infection.The Cochrane database of systematic reviews · 2018Pooled it
- Changing trends in the prevalence of H. pylori infection in Japan (1908-2003): a systematic review and meta-regression analysis of 170,752 individuals.Scientific reports · 2017Pooled it
- Pooled it
- Review
- Diagnosis and treatment ofFuture microbiology · 2025Review
- Causal relationship betweenRenal failure · 2024Article
- The chimeric UreB, FliD and Omp18 proteins for a sensitive and specific diagnosis ofIranian journal of microbiology · 2024Article
- Long-term Response of Helicobacter pylori Antibody Titer After Eradication Treatment in Middle-aged Japanese: JPHC-NEXT Study.Journal of epidemiology · 2023Article
- Helicobacter pylori Infection, Its Laboratory Diagnosis, and Antimicrobial Resistance: a Perspective of Clinical Relevance.Clinical microbiology reviews · 2022Review
- Seroepidemiological survey of the prevalence ofIJID regions · 2022Article
- Inverse time trends of peptic ulcer and reflux esophagitis show significant association with reduced prevalence ofAnnals of medicine · 2020Article
- Usefulness and Limitations of a Serum Screening System to Predict the Risk of Gastric Cancer.Internal medicine (Tokyo, Japan) · 2020Article
- Serum Pepsinogen Values in Japanese Junior High School Students With Reference to Helicobacter Pylori Infection.Journal of epidemiology · 2020Article
- Application of 16S rRNA gene sequencing inPeerJ · 2020Article
- Association between Helicobacter pylori infection, eradication and diabetes mellitus.Journal of diabetes investigation · 2019Article
- Diagnostic methods for Helicobacter pylori infection: ideals, options, and limitations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Serum anti-World journal of gastroenterology · 2018Article
- Article
- Overexpression of leucine-rich α2-glycoprotein-1 is a prognostic marker and enhances tumor migration in gastric cancer.Cancer science · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA number of noninvasive diagnostic tests are available to detect Helicobacter pylori infection. Data on serologic testing of children are lacking, however, and thus it remains unclear whether the serology cutoff points used for adults are appropriate for children.
methodsSerum and stool samples were obtained from 73 children who visited 5 hospitals in Japan between March 1993 and December 2009. Analysis of stool samples was carried out using an H pylori stool antigen enzyme-linked immunosorbent assay (HpSA ELISA), and serum antibodies to H pylori were examined using an antibody determination kit (E-Plate Eiken H pylori antibody). The validity of the serologic test was evaluated based on its sensitivity, specificity, and receiver operating characteristics curve.
resultsOf the 73 children included in this study, 34 were HpSA-positive and 39 were negative. Among the 34 HpSA-positive patients, 32 were IgG-positive and 2 were IgG-negative. Of the 39 patients who were HpSA-negative, 38 were IgG-negative and 1 was IgG-positive. The sensitivity, specificity, and positive likelihood ratio for IgG antibody testing were 91.2%, 97.4%, and 35.6, respectively, based on the recommended adult cutoff point of 10 U/ml. Among children, use of cutoff points in the range of 7 to 9 U/ml yielded optimal values for sensitivity and specificity, as well as a positive likelihood ratio.
conclusionsThe performance of the E-plate anti-H pylori IgG antibody test was comparable to that of the stool antigen test and is therefore suitable for epidemiologic studies of H pylori infection in large samples.
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