ArticleGenetics2014
Hitchhiking of deleterious alleles and the cost of adaptation in partially selfing species.
Article in Genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The evolution of tandem repeat sequences under partial selfing and different modes of selection.Heredity · 2026Article
- Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.Evolution; international journal of organic evolution · 2025Article
- Genomic implications of the repeated shift to self-fertilization across a species' geographic distribution.The Journal of heredity · 2025Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.bioRxiv : the preprint server for biology · 2024Article
- Polygenic selection to a changing optimum under self-fertilisation.PLoS genetics · 2024Article
- Indirect genetic effects are shaped by demographic history and ecology in Arabidopsis thaliana.Nature ecology & evolution · 2023Article
- Influence of the mutation load on the genomic composition of hybrids between outcrossing and self-fertilizing species.Ecology and evolution · 2023Article
- Genomic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes.PLoS genetics · 2023Article
- Interplay between extreme drift and selection intensities favors the fixation of beneficial mutations in selfing maize populations.Genetics · 2021Article
- Selective Sweeps Under Dominance and Inbreeding.G3 (Bethesda, Md.) · 2020Article
- Population Genomics of Transitions to Selfing in Brassicaceae Model Systems.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Effect of partial selfing and polygenic selection on establishment in a new habitat.Evolution; international journal of organic evolution · 2019Article
- Article
- Prediction of deleterious mutations in coding regions of mammals with transfer learning.Evolutionary applications · 2019Article
- The genetic architecture of genome-wide recombination rate variation in allopolyploid wheat revealed by nested association mapping.The Plant journal : for cell and molecular biology · 2018Article
- The Evolutionary Interplay between Adaptation and Self-Fertilization.Trends in genetics : TIG · 2017Review
- Genetic, Physical and Comparative Mapping of the Powdery Mildew Resistance GeneFrontiers in plant science · 2017Article
- On the Trail of Linked Selection.PLoS genetics · 2016Article
- Limits to Adaptation in Partially Selfing Species.Genetics · 2016Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-fertilization is generally seen to be disadvantageous in the long term. It increases genetic drift, which subsequently reduces polymorphism and the efficiency of selection, which also challenges adaptation. However, high selfing rates can increase the fixation probability of recessive beneficial mutations, but existing theory has generally not accounted for the effect of linked sites. Here, we analyze a model for the fixation probability of deleterious mutants that hitchhike with selective sweeps in diploid, partially selfing populations. Approximate analytical solutions show that, conditional on the sweep not being lost by drift, higher inbreeding rates increase the fixation probability of the deleterious allele, due to the resulting reduction in polymorphism and effective recombination. When extending the analysis to consider a distribution of deleterious alleles, as well as the average fitness increase after a sweep, we find that beneficial alleles generally need to be more recessive than the previously assumed dominance threshold (h < 1/2) for selfing to be beneficial from one-locus theory. Our results highlight that recombination aiding the efficiency of selection on multiple loci amplifies the fitness benefits of outcrossing over selfing, compared to results obtained from one-locus theory. This effect additionally increases the parameter range under which obligate outcrossing is beneficial over partial selfing.
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