ArticleNature biotechnology2014
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.
Article in Nature biotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 104 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
104 citing papers in PubMed, 168 citations in OpenAlex.
- Stem Cell Therapy for the Management of Type 1 Diabetes: Advances and Perspectives.Endocrine, metabolic & immune disorders drug targets · 2024Review
- Advanced therapy to cure diabetes: mission impossible is now possible?Frontiers in cell and developmental biology · 2024Review
- Bone morphogenetic protein-7 attenuates pancreatic damage under diabetic conditions and prevents progression to diabetic nephropathy via inhibition of ferroptosis.Frontiers in endocrinology · 2023Article
- Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration.International journal of molecular sciences · 2022Article
- β cell regeneration and novel strategies for treatment of diabetes (Review).Biomedical reports · 2022Review
- Stem cells differentiation into insulin-producing cells (IPCs): recent advances and current challenges.Stem cell research & therapy · 2022Review
- Pancreatic β cell regeneration induced by clinical and preclinical agents.World journal of stem cells · 2021Review
- Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review.Nutrients · 2020Review
- Mesenchymal stem cells promote pancreatic β-cell regeneration through downregulation of FoxO1 pathway.Stem cell research & therapy · 2020Article
- Mapping regulators of cell fate determination: Approaches and challenges.APL bioengineering · 2020Review
- Pancreatic β cell regeneration: To β or not to β.Current opinion in physiology · 2020Article
- STAT3 dictates β-cell apoptosis by modulating PTEN in streptozocin-induced hyperglycemia.Cell death and differentiation · 2020Article
- Organoids from the Human Fetal and Adult Pancreas.Current diabetes reports · 2019Review
- Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- How, When, and Where Do Human β-Cells Regenerate?Current diabetes reports · 2019Review
- Mesenchymal stem cells and immune disorders: from basic science to clinical transition.Frontiers of medicine · 2019Review
- Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture.Scientific reports · 2019Article
- Human beta cells generated from pluripotent stem cells or cellular reprogramming for curing diabetes.Regenerative engineering and translational medicine · 2019Article
- Essential Roles for the Non-Canonical IκB Kinases in Linking Inflammation to Cancer, Obesity, and Diabetes.Cells · 2019Review
- Pancreatic Progenitors: There and Back Again.Trends in endocrinology and metabolism: TEM · 2019Review
44 more citing papers are in PubMed but not listed here.
Corrections and comments
- Retraction · 2020-02-17Error in Data · Error in Methods · Results Not Reproducible ·
- Commented on by
- Retracted
Authors and funding
21 authors at 8 institutions in 6 countries.
Funding
Abstract
Reprogramming of pancreatic exocrine cells into cells resembling beta cells may provide a strategy for treating diabetes. Here we show that transient administration of epidermal growth factor and ciliary neurotrophic factor to adult mice with chronic hyperglycemia efficiently stimulates the conversion of terminally differentiated acinar cells to beta-like cells. Newly generated beta-like cells are epigenetically reprogrammed, functional and glucose responsive, and they reinstate normal glycemic control for up to 248 d. The regenerative process depends on Stat3 signaling and requires a threshold number of Neurogenin 3 (Ngn3)-expressing acinar cells. In contrast to previous work demonstrating in vivo conversion of acinar cells to beta-like cells by viral delivery of exogenous transcription factors, our approach achieves acinar-to-beta-cell reprogramming through transient cytokine exposure rather than genetic modification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.