ReviewCell cycle (Georgetown, Tex.)2013
Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.
Review in Cell cycle (Georgetown, Tex.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Evolvable soma theory of ageing: observations from the natural world.GeroScience · 2026Article
- A generator-matrix model quantifies the limited contribution of measured biomarkers to human mortality acceleration.medRxiv : the preprint server for health sciences · 2026Article
- Unsupervised characterization of 100,272 EHR patients identifies high-risk groups and comorbidities linked to premature aging.NPJ digital medicine · 2026Article
- Comparison of the frailty phenotype and frailty index for identifying vulnerable companion dogs.Scientific reports · 2025Article
- Aging by the clock and yet without a program.Nature aging · 2025Review
- Review
- Fundamental equations linking methylation dynamics to maximum lifespan in mammals.Nature communications · 2024Article
- Effects of Ginger (Biomolecules · 2024Review
- Article
- Gene expressions associated with longer lifespan and aging exhibit similarity in mammals.Nucleic acids research · 2023Article
- Aging, adaptation and maladaptation.Frontiers in aging · 2023Article
- Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases.Progress in brain research · 2023Article
- Modalities of aging in organisms with different strategies of resource allocation.Ageing research reviews · 2022Review
- Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components.Biogerontology · 2022Review
- Is Aging an Inevitable Characteristic of Organic Life or an Evolutionary Adaptation?Biochemistry. Biokhimiia · 2022Review
- Multigenerational downregulation of insulin/IGF-1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing.Evolution; international journal of organic evolution · 2022Article
- Why Gilgamesh failed: the mechanistic basis of the limits to human lifespan.Nature aging · 2022Review
- Nutritional components as mitigators of cellular senescence in organismal aging: a comprehensive review.Food science and biotechnology · 2022Review
- As predicted by hyperfunction theory, rapamycin treatment during development extends lifespan.Aging · 2022Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is not and cannot be programmed. Instead, aging is a continuation of developmental growth, driven by genetic pathways such as mTOR. Ironically, this is often misunderstood as a sort of programmed aging. In contrast, aging is a purposeless quasi-program or, figuratively, a shadow of actual programs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.