ArticleDevelopmental biology2014
A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling.
Article in Developmental biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Tyrosine Kinase Receptors, Inhibition, and Potential Role in the Pharmacotherapy of Retinal Disorders.Ophthalmology and therapy · 2026Review
- Glia generate distinct visual processing centres by locally inhibiting ERK activity in an optic lobe neuroepithelium.bioRxiv : the preprint server for biology · 2026Article
- ETS transcription factor pointed controls germline survival in Drosophila.PLoS genetics · 2025Article
- ETS transcription factors regulate precise matrix metalloproteinase expression and follicle rupture in Drosophila.Development (Cambridge, England) · 2024Article
- Integrative genomic analyses reveal putative cell type-specific targets of the Drosophila ets transcription factor Pointed.BMC genomics · 2024Article
- Energy metabolism modulates the regulatory impact of activators on gene expression.Development (Cambridge, England) · 2024Article
- Energy metabolism modulates the regulatory impact of activators on gene expression.bioRxiv : the preprint server for biology · 2023Article
- Ratiometric sensing of Pnt and Yan transcription factor levels confers ultrasensitivity to photoreceptor fate transitions in Drosophila.Development (Cambridge, England) · 2023Article
- Single cell RNA sequencing of the adult Drosophila eye reveals distinct clusters and novel marker genes for all major cell types.Communications biology · 2022Article
- Molecular inhibition of RAS signalling to target ageing and age-related health.Disease models & mechanisms · 2022Review
- A single-cell atlas and lineage analysis of the adult Drosophila ovary.Nature communications · 2020Article
- A context-dependent bifurcation in the Pointed transcriptional effector network contributes specificity and robustness to retinal cell fate acquisition.PLoS genetics · 2020Article
- Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression ofeLife · 2020Article
- A newly discovered neural stem cell population is generated by the optic lobe neuroepithelium during embryogenesis inDevelopment (Cambridge, England) · 2018Article
- Transcription factor Etv6 regulates functional differentiation of cross-presenting classical dendritic cells.The Journal of experimental medicine · 2018Article
- Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness inDevelopment (Cambridge, England) · 2018Article
- Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling.PLoS genetics · 2018Article
- Article
- Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification.Genes & development · 2018Article
- Simple Expression Domains Are Regulated by Discrete CRMs DuringG3 (Bethesda, Md.) · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The biochemical regulatory network downstream of receptor tyrosine kinase (RTK) signaling is controlled by two opposing ETS family members: the transcriptional activator Pointed (Pnt) and the transcriptional repressor Yan. A bistable switch model has been invoked to explain how pathway activation can drive differentiation by shifting the system from a high-Yan/low-Pnt activity state to a low-Yan/high-Pnt activity state. Although the model explains yan and pnt loss-of-function phenotypes in several different cell types, how Yan and Pointed protein expression dynamics contribute to these and other developmental transitions remains poorly understood. Toward this goal we have used a functional GFP-tagged Pnt transgene (Pnt-GFP) to perform a comparative study of Yan and Pnt protein expression throughout Drosophila development. Consistent with the prevailing model of the Pnt-Yan network, we found numerous instances where Pnt-GFP and Yan adopt a mutually exclusive pattern of expression. However we also observed many examples of co-expression. While some co-expression occurred in cells where RTK signaling is presumed low, other co-expression occurred in cells with high RTK signaling. The instances of co-expressed Yan and Pnt-GFP in tissues with high RTK signaling cannot be explained by the current model, and thus they provide important contexts for future investigation of how context-specific differences in RTK signaling, network topology, or responsiveness to other signaling inputs, affect the transcriptional response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.