ArticleBehavioural brain research2014
The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice.
Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Effects of natural deep hypothermia on cognitive abilities in mammals: hibernators and neonates.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Review
- Acute Comparative Analysis of Anesthetic Methods in Neonatal Mice (Mus musculus) Using Ultrasonic Vocalizations and Biochemical Markers.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Standardisation and future of preclinical echocardiography.Mammalian genome : official journal of the International Mammalian Genome Society · 2023Review
- A low-cost device for cryoanesthesia of neonatal rodents.HardwareX · 2023Article
- A Role of Complement in the Pathogenic Sequelae of Mouse Neonatal Germinal Matrix Hemorrhage.International journal of molecular sciences · 2022Article
- Article
- Effects of Rodent Thermoregulation on Animal Models in the Research Environment.Comparative medicine · 2018Review
- A Neonatal Mouse Spinal Cord Compression Injury Model.Journal of visualized experiments : JoVE · 2016Article
- A Common Phenotype Polymorphism in Mammalian Brains Defined by Concomitant Production of Prolactin and Growth Hormone.PloS one · 2016Article
- Response to Protocol Review Scenario: Protocol is acceptable.Lab animal · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Deep hypothermia (cryoanesthesia) is often used as general anesthesia during surgery in neonatal rodents. Neonatal cryoanesthesia has been used recently to generate somatic brain transgenic (SBT) mouse models via intracerebral ventricular injection of rAAV vectors into both non-transgenic mice and numerous transgenic mouse models. Since, the evaluation of cognition is one of the main experimental endpoints in many of these studies, we examined the consequences of brief neonatal cryoanesthesia on the physical development and mnemonic function of adult mice. Two groups of 129FVBF1 pups from reciprocal breeding crosses underwent cryoanesthesia for 6 min (Cryo6) or 12 min (Cryo12), respectively, within the first hours (<12h) of postnatal life. A group of pups separated from the nest and kept in ambient temperature of 33 °C for 6 min served as a control. Our results revealed that lowering the temperature of pups to ~8 °C (Cryo6) or ~5 °C (Cryo12) did not affect their body weight at pre-weaning stage and in the adulthood. The evaluation of cognitive function in adult mice revealed strong and comparable to control spatial reference, and context and tone fear memories of neonatally cryoanesthetized mice. Also, the experimental and control groups had comparable brain weight at the end of the study. Our results demonstrate that neonatal cryoanesthesia, lasting up to 12 min, has no adverse effects on the body weight of mice during development, and on their cognition in the adulthood.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.