ArticleBehavioural brain research2014
Acute ethanol exposure induces behavioural differences in two zebrafish (Danio rerio) strains: a time course analysis.
Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- The importance of understanding the ethology and ecology of the zebrafish, and of other fish species, in experimental research.Biologia futura · 2025Review
- Article
- Acute Administration of Ethanol and of a D1-Receptor Antagonist Affects the Behavior and Neurochemistry of Adult Zebrafish.Biomedicines · 2022Article
- Beyond bold versus shy: Zebrafish exploratory behavior falls into several behavioral clusters and is influenced by strain and sex.Biology open · 2022Article
- Sex-Specific Effects of Acute Ethanol Exposure on Locomotory Activity and Exploratory Behavior in Adult Zebrafish (Frontiers in pharmacology · 2022Article
- Article
- Which Zebrafish Strains Are More Suitable to Perform Behavioral Studies? A Comprehensive Comparison by Phenomic Approach.Biology · 2020Article
- Article
- Evaluation of the sensitivity spectrum of a video tracking system with zebrafish (Danio rerio) exposed to five different toxicants.Environmental science and pollution research international · 2017Article
- Zebrafish models in neuropsychopharmacology and CNS drug discovery.British journal of pharmacology · 2017Review
- Zebrafish Get Connected: Investigating Neurotransmission Targets and Alterations in Chemical Toxicity.Toxics · 2016Article
- Alcohol-induced behavioral changes in zebrafish: The role of dopamine D2-like receptors.Psychopharmacology · 2016Article
- Concentration, population, and context-dependent effects of AM251 in zebrafish.Psychopharmacology · 2016Article
- Differential effects of dopamine D1 and D 2/3 receptor antagonism on motor responses.Psychopharmacology · 2015Article
- An integrative analysis of ethanol tolerance and withdrawal in zebrafish (Danio rerio).Behavioural brain research · 2015Article
- Recent advances with a novel model organism: alcohol tolerance and sensitization in zebrafish (Danio rerio).Progress in neuro-psychopharmacology & biological psychiatry · 2014Review
- Induction of social behavior in zebrafish: live versus computer animated fish as stimuli.Zebrafish · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The zebrafish has been proposed as a model organism to study genetic effects influencing behaviour and also as a tool with which the mechanisms of the action of alcohol (ethanol or EtOH) in the vertebrate brain may be investigated. In the current study we exposed zebrafish from two genetically distinct strains (WIK and TU) to a computer animated image of a natural predator of this species, the Indian leaf fish. We measured the subjects' behavioural responses in the presence of different acute doses of alcohol (0.00, 0.25, 0.50, and 1.00% vol/vol) using an observation based event-recording method. We found fish of both strains to exhibit an atypical predator inspection response during the presentation of the animated predator image coupled with a classical fear response, increased jumping frequency. We found numerous alcohol induced behavioural changes and more importantly also revealed alcohol induced strain dependent changes as well, including different dose-response trajectories for WIK vs. TU in predator inspection response, general swimming activity, location of swimming (top vs. bottom half of the tank) and freezing. The results suggest that zebrafish of the TU strain may be more tolerant at least to lower doses of alcohol as compared to WIK. The characterization of strain differences in zebrafish will aid the identification of possible molecular mechanisms involved in alcohol's actions in the vertebrate brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.