ArticleJournal of biomedical informatics2014
The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research.
Article in Journal of biomedical informatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Methodological information extraction from randomized controlled trial publications: a pilot study.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2022Trial
- CMEO: a metadata-centric ontology for clinical studies exploration and harmonization assessment.BMC medical informatics and decision making · 2025Article
- Leveraging SNOMED CT for patient cohort identification over heterogeneous EHR data.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025Article
- Clinical Research Informatics: a Decade-in-Review.Yearbook of medical informatics · 2024Review
- IMGT/mAb-KG: the knowledge graph for therapeutic monoclonal antibodies.Frontiers in immunology · 2024Article
- Semantically enabling clinical decision support recommendations.Journal of biomedical semantics · 2023Article
- NeuroBridge: a prototype platform for discovery of the long-tail neuroimaging data.Frontiers in neuroinformatics · 2023Article
- Synthesizing evidence from clinical trials with dynamic interactive argument trees.Journal of biomedical semantics · 2022Article
- Improving the Estimation of Subgroup Effects for Clinical Trial Participants with Multimorbidity by Incorporating Drug Class-Level Information in Bayesian Hierarchical Models: A Simulation Study.Medical decision making : an international journal of the Society for Medical Decision Making · 2022Article
- Enabling Scientific Reproducibility through FAIR Data Management: An ontology-driven deep learning approach in the NeuroBridge Project.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2022Article
- Visual comprehension and orientation into the COVID-19 CIDO ontology.Journal of biomedical informatics · 2021Article
- Obstacles to the reuse of study metadata in ClinicalTrials.gov.Scientific data · 2020Article
- Missing lateral relationships in top-level concepts of an ontology.BMC medical informatics and decision making · 2020Article
- Natural Language Processing for the Evaluation of Methodological Standards and Best Practices of EHR-based Clinical Research.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020Article
- Improving reference prioritisation with PICO recognition.BMC medical informatics and decision making · 2019Article
- Semantic Provenance Graph for Reproducibility of Biomedical Research Studies: Generating and Analyzing Graph Structures from Published Literature.Studies in health technology and informatics · 2019Article
- ProvCaRe: Characterizing scientific reproducibility of biomedical research studies using semantic provenance metadata.International journal of medical informatics · 2019Article
- Desiderata for sharable computable biomedical knowledge for learning health systems.Learning health systems · 2018Article
- Quality assurance of chemical ingredient classification for the National Drug File - Reference Terminology.Journal of biomedical informatics · 2017Article
- Extending XNAT Platform with an Incremental Semantic Framework.Frontiers in neuroinformatics · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
To date, the scientific process for generating, interpreting, and applying knowledge has received less informatics attention than operational processes for conducting clinical studies. The activities of these scientific processes - the science of clinical research - are centered on the study protocol, which is the abstract representation of the scientific design of a clinical study. The Ontology of Clinical Research (OCRe) is an OWL 2 model of the entities and relationships of study design protocols for the purpose of computationally supporting the design and analysis of human studies. OCRe's modeling is independent of any specific study design or clinical domain. It includes a study design typology and a specialized module called ERGO Annotation for capturing the meaning of eligibility criteria. In this paper, we describe the key informatics use cases of each phase of a study's scientific lifecycle, present OCRe and the principles behind its modeling, and describe applications of OCRe and associated technologies to a range of clinical research use cases. OCRe captures the central semantics that underlies the scientific processes of clinical research and can serve as an informatics foundation for supporting the entire range of knowledge activities that constitute the science of clinical research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.