ArticleDevelopmental cell2013
miR-219 regulates neural precursor differentiation by direct inhibition of apical par polarity proteins.
Article in Developmental cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- MicroRNA and Proteomic Landscape of Brain Development.Neurochemical research · 2026Article
- MicroRNA as Potential Biomarkers and Their Pathogenesis in Multiple System Atrophy.International journal of molecular sciences · 2026Review
- Dual-Targeting miR-219 and miR-146a in Multiple Sclerosis: Bridging Myelin Repair and Neuroinflammation for Novel Therapeutic Insights.Cellular and molecular neurobiology · 2026Review
- MicroRNA-219 in the central nervous system: a potential theranostic approach.Research in pharmaceutical sciences · 2024Review
- 3D exploration of gene expression in chicken embryos through combined RNA fluorescence in situ hybridization, immunofluorescence, and clearing.BMC biology · 2024Article
- Transcriptional Regulators with Broad Expression in the Zebrafish Spinal Cord.bioRxiv : the preprint server for biology · 2024Article
- From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions.Acta neuropathologica · 2023Article
- Article
- Perspectives on Mechanisms Supporting Neuronal Polarity From Small Animals to Humans.Frontiers in cell and developmental biology · 2022Review
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- Daam2 couples translocation and clustering of Wnt receptor signalosomes through Rac1.Journal of cell science · 2021Article
- Insights Into Central Nervous System Glial Cell Formation and Function From Zebrafish.Frontiers in cell and developmental biology · 2021Review
- Hydroxychloroquine effects on miR-155-3p and miR-219 expression changes in animal model of multiple sclerosis.Metabolic brain disease · 2020Article
- Role of miR-124 in the regulation of retinoic acid-induced Neuro-2A cell differentiation.Neural regeneration research · 2020Article
- Epigenetic regulation of oligodendrocyte myelination in developmental disorders and neurodegenerative diseases.F1000Research · 2020Review
- Notch-mediated inhibition of neurogenesis is required for zebrafish spinal cord morphogenesis.Scientific reports · 2019Article
- Regulation of Polarity Protein Levels in the Developing Central Nervous System.Journal of molecular biology · 2018Review
- Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS.Journal of neuroinflammation · 2017Article
- Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish.Open biology · 2017Article
- Massive transcriptome sequencing of human spinal cord tissues provides new insights into motor neuron degeneration in ALS.Scientific reports · 2017Article
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3 authors at 1 institution in 1 country.
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Abstract
Asymmetric self-renewing division of neural precursors is essential for brain development. Partitioning-defective (Par) proteins promote self-renewal, and their asymmetric distribution provides a mechanism for asymmetric division. Near the end of neural development, most asymmetric division ends and precursors differentiate. This correlates with Par protein disappearance, but mechanisms that cause downregulation are unknown. MicroRNAs can promote precursor differentiation but have not been linked to Par protein regulation. We tested a hypothesis that microRNA miR-219 promotes precursor differentiation by inhibiting Par proteins. Neural precursors in zebrafish larvae lacking miR-219 function retained apical proteins, remained in the cell cycle, and failed to differentiate. miR-219 inhibited expression via target sites within the 3' untranslated sequence of pard3 and prkci mRNAs, which encode Par proteins, and blocking miR-219 access to these sites phenocopied loss of miR-219 function. We propose that negative regulation of Par protein expression by miR-219 promotes cell-cycle exit and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.