ArticleCell reports2013
Structural analysis uncovers lipid-binding properties of Notch ligands.
Article in Cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Article
- Azvudine Suppresses Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Targeting the Notch-HEY Signalling Pathway.International journal of molecular sciences · 2025Article
- UtilizingJournal of developmental biology · 2025Review
- Multiscale simulations reveal architecture of NOTCH protein and ligand specific features.Biophysical journal · 2025Article
- Structural and functional studies of the EGF20-27 region reveal new features of the human Notch receptor important for optimal activation.Structure (London, England : 1993) · 2024Article
- Functional characterization of 2,832 JAG1 variants supports reclassification for Alagille syndrome and improves guidance for clinical variant interpretation.American journal of human genetics · 2024Article
- Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force.Nature communications · 2024Article
- Toll-like receptors as a missing link in Notch signaling cascade during neurodevelopment.Frontiers in molecular neuroscience · 2024Article
- New tricks for an old pathway: emerging Notch-based biotechnologies and therapeutics.Trends in pharmacological sciences · 2023Review
- Mutations inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling.EMBO reports · 2021Article
- The developmental origins of Notch-driven intrahepatic bile duct disorders.Disease models & mechanisms · 2021Article
- Notch-Jagged signaling complex defined by an interaction mosaic.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Biophysics of Notch Signaling.Annual review of biophysics · 2021Review
- RNA Splicing: A Versatile Regulatory Mechanism in Pediatric Liver Diseases.Frontiers in molecular biosciences · 2021Review
- Association of Jagged1 expression with malignancy and prognosis in human pancreatic cancer.Cellular oncology (Dordrecht, Netherlands) · 2020Article
- GATA1-regulated JAG1 promotes ovarian cancer progression by activating Notch signal pathway.Protoplasma · 2020Article
- Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification.Human mutation · 2019Article
- Influence of the Assembly State on the Functionality of a Supramolecular Jagged1-Mimicking Peptide Additive.ACS omega · 2019Article
- Notch and interacting signalling pathways in cardiac development, disease, and regeneration.Nature reviews. Cardiology · 2018Review
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The Notch pathway is a core cell-cell signaling system in metazoan organisms with key roles in cell-fate determination, stem cell maintenance, immune system activation, and angiogenesis. Signals are initiated by extracellular interactions of the Notch receptor with Delta/Serrate/Lag-2 (DSL) ligands, whose structure is highly conserved throughout evolution. To date, no structure or activity has been associated with the extreme N termini of the ligands, even though numerous mutations in this region of Jagged-1 ligand lead to human disease. Here, we demonstrate that the N terminus of human Jagged-1 is a C2 phospholipid recognition domain that binds phospholipid bilayers in a calcium-dependent fashion. Furthermore, we show that this activity is shared by a member of the other class of Notch ligands, human Delta-like-1, and the evolutionary distant Drosophila Serrate. Targeted mutagenesis of Jagged-1 C2 domain residues implicated in calcium-dependent phospholipid binding leaves Notch interactions intact but can reduce Notch activation. These results reveal an important and previously unsuspected role for phospholipid recognition in control of this key signaling system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.