Observational studyFertility and sterility2014
Semen quality and time to pregnancy: the Longitudinal Investigation of Fertility and the Environment Study.
Observational study in Fertility and sterility, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-correlation of Sperm Morphology and DNA Fragmentation Index.Reproductive sciences (Thousand Oaks, Calif.) · 2025Pooled it
- Pooled it
- Male cellular telephone exposure, fecundability, and semen quality: results from two preconception cohort studies.Human reproduction (Oxford, England) · 2021Pooled it
- Longitudinal semen parameter assessments and live birth: variability and implications for treatment strategies.Fertility and sterility · 2022Trial
- Sperm-Associated Mercury Species Levels Determine Its Impairment: Evidence from Paired Analyses of Whole Semen and Seminal Plasma.Biological trace element research · 2026Article
- An Artificial Intelligence-Based Computer Vision Model for Human Sperm Concentration, Motility, and Kinematics Analysis.Smart medicine · 2026Article
- A prospective study of semen quality and fecundability among North American couples planning pregnancy.Andrology · 2026Article
- Predicting natural conception leading to live birth for couples with infertility: a single-centre population-based cohort study of 7086 couples.Human reproduction open · 2026Article
- Acute stress induction downregulates RHOX-5 gene expression causing altered fertility indices in MALE Wistar rats.JBRA assisted reproduction · 2026Article
- A machine learning approach using semen parameters and sperm mitochondrial DNA copy number to predict couples' fecundity.F&S reports · 2025Article
- Normozoospermic infertile men possess subpopulations of sperm varying in DNA accessibility, relating to differing reproductive outcomes.Human reproduction (Oxford, England) · 2025Article
- Automatic identification of human spermatozoa with zona pellucida-binding capability using deep learning.Human reproduction open · 2025Article
- Observational
- Stress increases sperm respiration and motility in mice and men.Nature communications · 2024Article
- Associations between Sperm Epigenetic Age and Semen Parameters: An Evaluation of Clinical and Non-Clinical Cohorts.Current issues in molecular biology · 2024Article
- Association between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation.Frontiers in endocrinology · 2024Article
- Targeted Amino Acids Profiling of Human Seminal Plasma from Teratozoospermia Patients Using LC-MS/MS.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Association of living environmental and occupational factors with semen quality in chinese men: a cross-sectional study.Scientific reports · 2023Article
- Male infertility.Nature reviews. Disease primers · 2023Review
- Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
objectiveTo assess semen parameters and couple fecundity as measured by time to pregnancy (TTP).
designObservational prospective cohort with longitudinal measurement of TTP.
settingSixteen Michigan/Texas counties. PATIENT(S): A total of 501 couples discontinuing contraception were followed for 1 year while trying to conceive; 473 men (94%) provided one semen sample, and 80% provided two samples. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Using prospectively measured TTP, fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated for 36 individual semen quality parameters accounting for repeated semen samples, time off contraception, abstinence, enrollment site, and couples' ages, body mass indices, and serum cotinine concentrations. RESULT(S): In adjusted models, semen quality parameters were associated with significantly shorter TTP as measured by FORs >1: percent motility, strict and traditional morphology, sperm head width, elongation factor, and acrosome area. Significantly longer TTPs or FORs <1 were observed for morphologic categories amorphous and round sperm heads and neck/midpiece abnormalities. No semen quality parameters achieved significance when simultaneously modeling all other significant semen parameters and covariates, except for percent coiled tail when adjusting for sperm concentration (FOR 0.99; 95% CI 0.99-1.00). Male age was consistently associated with reduced couple fecundity (FOR 0.96; 95% CI 0.93-0.99), reflecting a longer TTP across all combined models. Female but not male body mass index also conferred a longer TTP (FOR 0.98; 95% CI 0.96-0.99). CONCLUSION(S): Several semen measures were significantly associated with TTP when modeled individually but not jointly and in the context of relevant couple-based covariates.
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