ArticleBiological psychiatry2014
Neural correlates of impaired cognitive control over working memory in schizophrenia.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A randomized clinical trial to evaluate feasibility, tolerability, and preliminary target engagement for a novel executive working memory training in adolescents with ADHD.Behaviour research and therapy · 2024Trial
- Flexibility Retained: Unimpaired Updating of Expectations in Schizophrenia.Behavioral sciences (Basel, Switzerland) · 2024Article
- Older adults compensate for switch, but not mixing costs, relative to younger adults on an intrinsically cued task switching experiment.Frontiers in aging neuroscience · 2023Article
- Principal component analysis suggests multiple dimensions of memory inhibition that are differentially affected by age.Frontiers in psychology · 2022Article
- Age, Sex, and Inhibitory Control: Identifying a Specific Impairment in Memorial, But Not Perceptual, Inhibition in Older Women.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Article
- GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease.Seminars in cell & developmental biology · 2021Review
- Behavioral measures of attention and cognitive control during a new auditory working memory paradigm.Behavior research methods · 2020Article
- Metacognitive preserved generation strategy benefits for both younger and elderly participants with schizophrenia.PloS one · 2020Article
- Stimuli may have little impact on the deficit of visual working memory accuracy in first-episode schizophrenia.Neuropsychiatric disease and treatment · 2019Article
- Inhibitory Selection Mechanisms in Clinically Healthy Older and Younger Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2018Article
- Medications Used for Cognitive Enhancement in Patients With Schizophrenia, Bipolar Disorder, Alzheimer's Disease, and Parkinson's Disease.Frontiers in psychiatry · 2018Review
- Perceptual and memory inhibition deficits in clinically healthy older adults are associated with region-specific, doubly dissociable patterns of cortical thinning.Behavioral neuroscience · 2017Article
- Effects of proactive interference on non-verbal working memory.Cognitive processing · 2017Article
- Chronic Nicotine Treatment During Adolescence Attenuates the Effects of Acute Nicotine in Adult Contextual Fear Learning.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Article
- Transdiagnostic neural markers of emotion-cognition interaction in psychotic disorders.Journal of abnormal psychology · 2016Article
- Impaired retrieval processes evident during visual working memory in schizophrenia.Schizophrenia research. Cognition · 2016Article
- Exposure to childhood trauma is associated with altered n-back activation and performance in healthy adults: implications for a commonly used working memory task.Brain imaging and behavior · 2016Article
- Meta-Analysis of Functional Neuroimaging and Cognitive Control Studies in Schizophrenia: Preliminary Elucidation of a Core Dysfunctional Timing Network.Frontiers in psychology · 2016Article
- MAM (E17) rodent developmental model of neuropsychiatric disease: disruptions in learning and dysregulation of nucleus accumbens dopamine release, but spared executive function.Psychopharmacology · 2015Article
- Neural correlates of aberrant emotional salience predict psychotic symptoms and global functioning in high-risk and first-episode psychosis.Social cognitive and affective neuroscience · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundOne of the most common deficits in patients with schizophrenia (SZ) is in working memory (WM), which has wide-reaching impacts across cognition. However, previous approaches to studying WM in SZ have used tasks that require multiple cognitive-control processes, making it difficult to determine which specific cognitive and neural processes underlie the WM impairment.
methodsWe used functional magnetic resonance imaging to investigate component processes of WM in SZ. Eighteen healthy controls (HCs) and 18 patients with SZ performed an item-recognition task that permitted separate neural assessments of 1) WM maintenance, 2) inhibition, and 3) interference control in response to recognition probes.
resultsBefore inhibitory demands, posterior ventrolateral prefrontal cortex (VLPFC), an area involved in WM maintenance, was activated to a similar degree in both HCs and patients, indicating preserved maintenance operations in SZ. When cued to inhibit items from WM, HCs showed reduced activation in posterior VLPFC, commensurate with appropriately inhibiting items from WM. However, these inhibition-related reductions were absent in patients. When later probed with items that should have been inhibited, patients showed reduced behavioral performance and increased activation in mid-VLPFC, an area implicated in interference control. A mediation analysis indicated that impaired inhibition led to increased reliance on interference control and reduced behavioral performance.
conclusionsIn SZ, impaired control over memory, manifested through proactive inhibitory deficits, leads to increased reliance on reactive interference-control processes. The strain on interference-control processes results in reduced behavioral performance. Thus, inhibitory deficits in SZ may underlie widespread impairments in WM and cognition.
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