ArticleCurrent biology : CB2013
Meiotic double-strand breaks uncover and protect against mitotic errors in the C. elegans germline.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells.PLoS genetics · 2024Article
- DNA repair, recombination, and damage signaling.Genetics · 2022Review
- Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.PLoS genetics · 2021Article
- JMJD-1.2 controls multiple histone post-translational modifications in germ cells and protects the genome from replication stress.Scientific reports · 2018Article
- Meiosis.WormBook : the online review of C. elegans biology · 2017Review
- The p53-like Protein CEP-1 Is Required for Meiotic Fidelity in C. elegans.Current biology : CB · 2016Article
- Intermittent Stem Cell Cycling Balances Self-Renewal and Senescence of the C. elegans Germ Line.PLoS genetics · 2016Article
- Manipulation of Karyotype in Caenorhabditis elegans Reveals Multiple Inputs Driving Pairwise Chromosome Synapsis During Meiosis.Genetics · 2015Article
- TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response.The Journal of cell biology · 2015Article
- Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans.The Journal of cell biology · 2015Article
- DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.PLoS genetics · 2015Article
- The meiotic checkpoint network: step-by-step through meiotic prophase.Cold Spring Harbor perspectives in biology · 2014Review
- Germ-granule components prevent somatic development in the C. elegans germline.Current biology : CB · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In sexually reproducing multicellular organisms, genetic information is propagated via the germline, the specialized tissue that generates haploid gametes. The C. elegans germline generates gametes in an assembly line-like process-mitotic divisions under the control of the stem cell niche produce nuclei that, upon leaving the niche, enter into meiosis and progress through meiotic prophase [1]. Here, we characterize the effects of perturbing cell division in the mitotic region of the C. elegans germline. We show that mitotic errors result in a spindle checkpoint-dependent cell-cycle delay, but defective nuclei are eventually formed and enter meiosis. These defective nuclei are eliminated by programmed cell death during meiotic prophase. The cell death-based removal of defective nuclei does not require the spindle checkpoint but instead depends on the DNA damage checkpoint. Removal of nuclei resulting from errors in mitosis also requires Spo11, the enzyme that creates double-strand breaks to initiate meiotic recombination. Consistent with this, double-strand breaks are increased in number and persist longer in germlines with mitotic defects. These findings reveal that the process of initiating meiotic recombination inherently selects against nuclei with abnormal chromosomal content generated by mitotic errors, thereby ensuring the genomic integrity of gametes.
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Registered trials
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