Evidence map›Paper›PMID 24239095›Full record

ArticleAnnals of epidemiology2014

Diet and lifestyle factors and risk of subtypes of esophageal and gastric cancers: classification tree analysis.

Stephanie A Navarro Silvera, Susan T Mayne, Marilie D Gammon, Thomas L Vaughan, Wong-Ho Chow, Joel A Dubin, Robert Dubrow, Janet L Stanford, A Brian West, Heidrun Rotterdam and 2 more

Open access · greenAbstract read
In one paragraph

Article in Annals of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 4 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
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  11. Dietary patterns and cancer risk.Nature reviews. Cancer · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 2 countries.

Stephanie A Navarro SilveraDepartment of Health and Nutrition Sciences, Montclair State University, Montclair, NJ. Electronic address: silveras@mail.montclair.edu.
Susan T MayneDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT.
Marilie D GammonDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC.
Thomas L VaughanDepartment of Epidemiology, University of Washington, Seattle, 98195 WA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, 98109 WA.
Wong-Ho ChowDepartment of Epidemiology, The University of Texas, MD Anderson Cancer Center, Houston, TX.
Joel A DubinDepartment of Statistics and Actuarial Science, School of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada.
Robert DubrowDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT.
Janet L StanfordDepartment of Epidemiology, University of Washington, Seattle, 98195 WA.
A Brian WestDepartment of Pathology, Yale School of Medicine, New Haven, CT.
Heidrun RotterdamDepartment of Pathology, Columbia University, New York, NY.
William J BlotInternational Epidemiology Institute, Rockville, MD.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT.
Yale University · USUniversity of Washington · USColumbia University · USInternational Epidemiology Institute · USMontclair State University · USThe University of Texas MD Anderson Cancer Center · USUniversity of North Carolina at Chapel Hill · USUniversity of Waterloo · CA

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
ESTABLISHED INVESTIGATOR AWARD IN CANCER PREVENTION AND CONTROLK05CA124911 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L · 2007 to 2016
$1.6M
Exploring Sociodemographic and Behavioral Factors Underlying Racial/Ethnic DisparK01CA157690 · NCI · MONTCLAIR STATE UNIVERSITY · PI SILVERA, STEPHANIE ANNE NAVARRO · 2012 to 2015
$555k
BIOSTATISTICAL &ANALYTICAL SUPPORT SERVICESN01CP040501 · CP · WESTAT, INC. · PI LANNOM, LINDA B · 1994 to 1996
–
SURVEILLANCE EPIDEMIOLOGY AND END RESULTSN01CN005230 · CN · FRED HUTCHINSON CANCER RESEARCH CENTER · PI THOMAS, DAVID B · 1990 to 1996
–
EPIDEMIOLOGIC STUDY OF ESOPHAGEAL/GASTRIC ADENOCARCINOMAU01CA057923 · NCI · YALE UNIVERSITY · PI RISCH, HARVEY A · 1992 to 1995
–
EPIDEMIOLOGIC STUDY OF ADENOCARCINOMAS OF THE ESOPHAGUSU01CA057949 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VAUGHAN, THOMAS L · 1992 to 1995
–
ADENOCARCINOMAS OF THE ESOPHAGUS AND GASTRIC CARDIAU01CA057983 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GAMMON, MARILIE D · 1992 to 1995
–
NCI NIH HHS K01 CA157690NCI NIH HHS K05 CA124911NCI NIH HHS N01 CN005230NCI NIH HHS N01-CN05230NCI NIH HHS N01 CP040501NCI NIH HHS N02-CP40501NCI NIH HHS P30 CA016672NCI NIH HHS U01 CA057923NCI NIH HHS U01 CA057949NCI NIH HHS U01 CA057983NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30-ES10126
6 · The paper itself

Abstract

purposeAlthough risk factors for squamous cell carcinoma of the esophagus and adenocarcinomas of the esophagus (EA), gastric cardia (GC), and other (noncardia) gastric (OG) sites have been identified, little is known about interactions among risk factors. We sought to examine interactions of diet, other lifestyle, and medical factors with risks of subtypes of esophageal and gastric cancers.

methodsWe used classification tree analysis to analyze data from a population-based case-control study (1095 cases, 687 controls) conducted in Connecticut, New Jersey, and western Washington State.

resultsFrequency of reported gastroesophageal reflux disease symptoms was the most important risk stratification factor for EA, GC, and OG, with dietary factors (EA, OG), smoking (EA, GC), wine intake (GC, OG), age (OG), and income (OG) appearing to modify the risk of these cancer sites. For esophageal squamous cell carcinoma, smoking was the most important risk stratification factor, with gastroesophageal reflux disease, income, race, noncitrus fruit, and energy intakes further modifying risk.

conclusionVarious combinations of risk factors appear to interact to affect risk of each cancer subtype. Replication of these data mining analyses are required before suggesting causal pathways; however, the classification tree results are useful in partitioning risk and mapping multilevel interactions among risk variables.

Indexed as

DietLife StyleAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Squamous CellCase-Control StudiesConnecticutEsophageal NeoplasmsFeeding BehaviorFemaleGastroesophageal RefluxHumansIncidenceLogistic ModelsCARTClassification treeDietEsophageal adenocarcinomaGastric cardia adenocarcinomaGastroesophageal reflux disease

Identifiers

PMID24239095
PMCPMC4006990
OpenAlexW2116135697

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.