ReviewTrends in neurosciences2014
The neuroimmune basis of fatigue.
Review in Trends in neurosciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07161245 (A Randomized Clinical Trial on the Improvement of Fatigue in Patients With Primary Biliary Cholangitis by Implementation of a Multimodal Rehabilitation Program and Study of Its Pathophysiological Mechanisms), which is not on this map. Cited by 174 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Clinical Trial on the Improvement of Fatigue in Patients With Primary Biliary Cholangitis by Implementation of a Multimodal Rehabilitation Program and Study of Its Pathophysiological Mechanisms
Who cites it
174 citing papers in PubMed, 7 syntheses or guidelines pooled it, 332 citations in OpenAlex.
- Effect of Perioperative Ketamine and Esketamine on Postoperative Fatigue: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Medicina (Kaunas, Lithuania) · 2026Pooled it
- The impact of ustekinumab and tumor necrosis factor antagonists on extraintestinal manifestations of Crohn's disease: a systematic review and meta-analysis.Frontiers in pharmacology · 2026Pooled it
- Optimized exercise prescription for alleviating cancer-related fatigue in breast cancer survivors after primary treatment: a systematic review and dose-response network meta-analysis.Frontiers in public health · 2026Pooled it
- Pooled it
- Frequency of Neurologic Manifestations in COVID-19: A Systematic Review and Meta-analysis.Neurology · 2021Pooled it
- Genetic variants at theRMD open · 2021Pooled it
- Examining techniques for measuring the effects of nutrients on mental performance and mood state.European journal of nutrition · 2016Pooled it
- Trial
- Randomized Controlled Phase II Evaluation of Two Dose Levels of Bupropion Versus Placebo for Sexual Desire in Female Cancer Survivors: NRG-CC004.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Trial
- Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.Scientific reports · 2019Trial
- Lipopolysaccharide Alters Motivated Behavior in a Monetary Reward Task: a Randomized Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Exercise is an effective treatment for positive valence symptoms in major depression.Journal of affective disorders · 2017Trial
- Trial
- Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial.BMC psychiatry · 2015Trial
- Activation of the cGAS-STING pathway contributes to cancer-related fatigue in a murine model of head and neck cancer.Brain, behavior, and immunity · 2026Article
- Dissociating Fatigue and Fatigability in Multiple Sclerosis: The Role of Cognitive Processing Speed.European journal of neurology · 2026Article
- Biomarker changes during long-term noninvasive ventilation in obesity hypoventilation syndrome: a prospective observational study.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Article
- Fatigue in Sjögren's Disease - Integrating Biomedical and Psychosocial Aspects: A Narrative Review.Rheumatology and therapy · 2026Review
- Eating during immunotherapy sessions: a cross-sectional study of meal quality in patients with rheumatic diseases undergoing intravenous therapy with immunomodulators.Clinical rheumatology · 2026Article
114 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
The exact nature and pathophysiology of fatigue remain largely elusive despite its high prevalence in physically ill patients. Studies on the relationship between the immune system and the central nervous system provide a new perspective on the mechanisms of fatigue. Inflammatory mediators that are released by activated innate immune cells at the periphery and in the central nervous system alter the metabolism and activity of neurotransmitters, generate neurotoxic compounds, decrease neurotrophic factors, and profoundly disturb the neuronal environment. The resulting alterations in fronto-striatal networks together with the activation of insula by inflammatory interoceptive stimuli underlie the many dimensions of fatigue including reduced incentive motivation, decreased behavioral flexibility, uncertainty about usefulness of actions, and awareness of fatigue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.