ArticleAddictive behaviors2014
Rate of progression from first use to dependence on cocaine or opioids: a cross-substance examination of associated demographic, psychiatric, and childhood risk factors.
Article in Addictive behaviors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Impact of adverse childhood experiences on analgesia-related outcomes: a systematic review.British journal of anaesthesia · 2025Pooled it
- Peripheral neurotrophin levels during controlled crack/cocaine abstinence: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Prevalence of childhood maltreatment among people with opioid use disorder: A systematic review and meta-analysis.Drug and alcohol dependence · 2021Pooled it
- Exploration of the telescoping effect among not-in-treatment, intensive heroin-using research volunteers.Drug and alcohol dependence · 2015Trial
- Involvement of the dorsal raphe serotonin system in basal and punished heroin self-administration and stress-induced reinstatement in male and female rats.Psychopharmacology · 2026Article
- Introduction to Helping to End Addiction Long-Term Prevention Cooperative: Overview and Strategies.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- Does polygenic risk for substance-related traits predict ages of onset and progression of symptoms?Addiction (Abingdon, England) · 2023Article
- Misuse of Prescription Opioids and Suicidal Behaviors Among Black Adolescents: Findings from the 2017 and 2019 Youth Risk Behavior Survey.Journal of racial and ethnic health disparities · 2023Article
- Effects of sex and estrous cycle on intravenous oxycodone self-administration and the reinstatement of oxycodone-seeking behavior in rats.bioRxiv : the preprint server for biology · 2023Article
- Effects of sex and estrous cycle on intravenous oxycodone self-administration and the reinstatement of oxycodone-seeking behavior in rats.Frontiers in behavioral neuroscience · 2023Article
- Bidirectional influence of heroin and cocaine escalation in persons with dual opioid and cocaine dependence diagnoses.Experimental and clinical psychopharmacology · 2022Article
- Circuit and neuropeptide mechanisms of the paraventricular thalamus across stages of alcohol and drug use.Neuropharmacology · 2021Review
- The importance of examining sex differences in animal models validated to induce an addiction-like phenotype.Pharmacology, biochemistry, and behavior · 2021Article
- Females develop features of an addiction-like phenotype sooner during withdrawal than males.Psychopharmacology · 2021Article
- A buprenorphine-validated rat model of opioid use disorder optimized to study sex differences in vulnerability to relapse.Psychopharmacology · 2021Article
- Adolescent cannabis and tobacco use are associated with opioid use in young adulthood-12-year longitudinal study in an urban cohort.Addiction (Abingdon, England) · 2021Article
- Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.Exploration of medicine · 2021Article
- Reducing health disparities among black individuals in the post-treatment environment.Journal of ethnicity in substance abuse · 2020Article
- Article
- Challenges for Women Entering Treatment for Opioid Use Disorder.Current psychiatry reports · 2020Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA number of demographic factors, psychiatric disorders, and childhood risk factors have been associated with cocaine dependence (CD) and opioid dependence (OD), but little is known about their relevance to the rate at which dependence develops. Identification of the subpopulations at elevated risk for rapid development of dependence and the risk factors that accelerate the course of dependence is an important public health goal.
methodsData were derived from cocaine dependent (n=6333) and opioid dependent (n=3513) participants in a multi-site study of substance dependence. Mean age was approximately 40 and 40% of participants were women; 51.9% of cocaine dependent participants and 29.5% of opioid dependent participants self-identified as Black/African-American. The time from first use to dependence was calculated for each substance and a range of demographic, psychiatric, and childhood risk factors were entered into ordinal logistic regression models to predict the (categorical) transition time to CD and OD.
resultsIn both the cocaine and opioid models, conduct disorder and childhood physical abuse predicted rapid development of dependence and alcohol and nicotine dependence diagnoses were associated with slower progression to CD or OD. Blacks/African Americans were at greater risk than European Americans to progress rapidly to OD.
conclusionsOnly a subset of factors known to be associated with CD and OD predicted the rate at which dependence developed. Nearly all were common to cocaine and opioids, suggesting that sources of influence on the timing of transitions to dependence are shared across the two substances.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.