ArticleBMC musculoskeletal disorders2013
Birth prevalence for congenital limb defects in the northern Netherlands: a 30-year population-based study.
Article in BMC musculoskeletal disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- A Practical Prenatal Ultrasound Classification System for Lower Limb Anomalies-PRELLIM Classification.Prenatal diagnosis · 2025Pooled it
- Congenital Asymmetrical Multiple Limb Deficiency in 1-Year-Old Male Child: A Case Report.Journal of orthopaedic case reports · 2026Article
- Whole exome sequencing uncovers genetic syndromes and putative candidate genes underlying orofacial clefts presenting with limb abnormalities in a Sub-Saharan African cohort.BMC medical genomics · 2026Article
- Whole Exome Sequencing Uncovers Genetic Syndromes Associated with Orofacial Clefts presenting with Limb abnormalities in a Sub-Saharan African cohort.Research square · 2025Article
- The Influence of the Introduction of Fetal Anomaly Scans on Pregnancy Terminations in Cases of Upper Limb Anomalies: A Retrospective Cohort Study From 2000 to 2023.Prenatal diagnosis · 2025Article
- Global, regional, and national burden of congenital musculoskeletal and limb anomalies, 1990-2021: a systematic analysis of the global burden of disease in 2021.Tropical medicine and health · 2025Article
- Phenotype-to-Genotype Description of Prenatal Suspected and Postnatal Discovered Upper Limb Anomalies: A Retrospective Cohort Study.Prenatal diagnosis · 2025Article
- Burden of congenital and hereditary anomalies in the population of Azad Jammu and Kashmir, Pakistan.Pakistan journal of medical sciences · 2024Article
- Development and Production of a Children's Upper-Limb Cycling Adapter Using 3D Printing.Materials (Basel, Switzerland) · 2024Article
- Surgical Reconstruction for the Triphalangeal Thumb.Plastic and reconstructive surgery. Global open · 2023Article
- Maternal Cigarette Smoking and Congenital Upper and Lower Limb Differences: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- The changing epidemiology of syndactyly in Chinese newborns: a nationwide surveillance-based study.BMC pregnancy and childbirth · 2023Article
- Intellectual Characteristics in Children With Congenital Unilateral Upper Limb Deficiencies.Cureus · 2023Article
- Congenital limb defects in a married female population of the Rahim Yar Khan District in Pakistan.Asian biomedicine : research, reviews and news · 2021Article
- The power of zebrafish models for understanding the co-occurrence of craniofacial and limb disorders.Genesis (New York, N.Y. : 2000) · 2021Review
- Two Cases of Preaxial Polydactyly of the Foot: Important Implications for Plastic Surgeons.Plastic and reconstructive surgery. Global open · 2021Article
- Rehabilitation Approach for a Child with Cerebral Palsy and Upper Limb Deficiency.Progress in rehabilitation medicine · 2021Article
- Etiological diagnosis in limb reduction defects and the number of affected limbs: A population-based study in the Northern Netherlands.American journal of medical genetics. Part A · 2020Article
- Orofaciodigital syndrome type II (Mohr syndrome): a case report.BMC musculoskeletal disorders · 2020Article
- Perinatal outcomes of infants with congenital limb malformations: an observational study from a tertiary referral center in Central Europe.BMC pregnancy and childbirth · 2020Observational
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7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReported birth prevalences of congenital limb defects (CLD) vary between countries: from 13/10,000 in Finland for the period 1964-1977 to 30.4/10,000 births in Scotland from 1964-1968. Epidemiological studies permit the timely detection of trends in CLD and of associations with other birth defects. The aim of this study is to describe the birth prevalence of CLD in the northern Netherlands.
methodsIn a population-based, epidemiological study we investigated the birth prevalences of CLD for 1981-2010. Data were collected by the European Surveillance of Congenital Anomalies in the northern Netherlands (EUROCAT-NNL). We excluded malpositions, club foot, and dislocation/dysplasia of hips or knees. Trends were analysed for the 19-year period 1992-2010 using χ² tests, as well as CLD association with anomalies affecting other organs.
resultsThe birth prevalence of CLD was 21.1/10,000 births for 1981-2010. There was an overall decrease in non-syndromic limb defects (P = 0.023) caused by a decrease in the prevalence of non-syndromic syndactyly (P < 0.01) in 1992-2010. Of 1,048 children with CLD, 55% were males, 57% had isolated defects, 13% had multiple congenital anomalies (MCA), and 30% had a recognised syndrome. The upper:lower limb ratio was 2:1, and the left:right side ratio was 1.2:1. Cardiovascular and urinary tract anomalies were common in combination with CLD (37% and 25% of cases with MCA). Digestive-tract anomalies were significantly associated with CLD (P = 0.016).
conclusionsThe birth prevalence of CLD in the northern Netherlands was 21.1/10,000 births. The birth prevalence of non-syndromic syndactyly dropped from 5.2/10,000 to 1.1/10,000 in 1992-2010.
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