Evidence map›Paper›PMID 24237862›Full record

ReviewJournal of cellular and molecular medicine2014

A systems biology view of blood vessel growth and remodelling.

Elizabeth A Logsdon, Stacey D Finley, Aleksander S Popel, Feilim Mac Gabhann

Open access · goldAbstract readReview
In one paragraph

Review in Journal of cellular and molecular medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it, 153 citations in OpenAlex.

  1. Pooled it
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  8. First-Order Speckle Statistics for the Detection of Microstructural Anisotropy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Elizabeth A LogsdonInstitute for Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Stacey D Finley
Aleksander S Popel
Feilim Mac Gabhann
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Systems Biology of Angiogenesis in Peripheral Arterial DiseaseR01HL101200 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2010 to 2022
$10.7M
Predictive experiment-based multiscale models of the tumor immune microenvironment and immunotherapy in breast cancerR01CA138264 · NCI · JOHNS HOPKINS UNIVERSITY · PI POPEL, ALEKSANDER S. · 2009 to 2023
$8.1M
Endothelial cell decisions integrate soluble and matrix-bound VEGF gradientsR00HL093219 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MAC GABHANN, FEILIM C · 2009 to 2011
$746k
Predictive model of pro- and anti-angiogenic factors involved in breast cancerF32CA154213 · NCI · JOHNS HOPKINS UNIVERSITY · PI FINLEY, STACEY DELERIA · 2010 to 2012
$121k
NCI NIH HHS F32 CA154213NCI NIH HHS R01 CA138264NHLBI NIH HHS R00 HL093219NHLBI NIH HHS R01 HL101200
6 · The paper itself

Abstract

Blood travels throughout the body in an extensive network of vessels - arteries, veins and capillaries. This vascular network is not static, but instead dynamically remodels in response to stimuli from cells in the nearby tissue. In particular, the smallest vessels - arterioles, venules and capillaries - can be extended, expanded or pruned, in response to exercise, ischaemic events, pharmacological interventions, or other physiological and pathophysiological events. In this review, we describe the multi-step morphogenic process of angiogenesis - the sprouting of new blood vessels - and the stability of vascular networks in vivo. In particular, we review the known interactions between endothelial cells and the various blood cells and plasma components they convey. We describe progress that has been made in applying computational modelling, quantitative biology and high-throughput experimentation to the angiogenesis process.

Indexed as

Neovascularization, PhysiologicSystems BiologyAnimalsEndothelium, VascularHumansModels, Biologicalangiogenesiscomputational modelmathematical modelmulti-scale modellingsystems biology

Identifiers

PMID24237862
PMCPMC4190897
OpenAlexW1984775455

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.