ArticleBMC systems biology2013
Rosen's (M,R) system in process algebra.
Article in BMC systems biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The essence of life revisited: how theories can shed light on it.Theory in biosciences = Theorie in den Biowissenschaften · 2022Article
- Considerations for using isolated cell systems to understand cardiac metabolism and biology.Journal of molecular and cellular cardiology · 2021Review
- A metabocentric view of cardiac remodeling.Current opinion in physiology · 2019Article
- Metabolic Coordination of Physiological and Pathological Cardiac Remodeling.Circulation research · 2018Review
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Authors and funding
2 authors.
Funding
Abstract
backgroundRobert Rosen's Metabolism-Replacement, or (M,R), system can be represented as a compact network structure with a single source and three products derived from that source in three consecutive reactions. (M,R) has been claimed to be non-reducible to its components and algorithmically non-computable, in the sense of not being evaluable as a function by a Turing machine. If (M,R)-like structures are present in real biological networks, this suggests that many biological networks will be non-computable, with implications for those branches of systems biology that rely on in silico modelling for predictive purposes.
resultsWe instantiate (M,R) using the process algebra Bio-PEPA, and discuss the extent to which our model represents a true realization of (M,R). We observe that under some starting conditions and parameter values, stable states can be achieved. Although formal demonstration of algorithmic computability remains elusive for (M,R), we discuss the extent to which our Bio-PEPA representation of (M,R) allows us to sidestep Rosen's fundamental objections to computational systems biology.
conclusionsWe argue that the behaviour of (M,R) in Bio-PEPA shows life-like properties.
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