ReviewAlimentary pharmacology & therapeutics2014
Review article: vitamin D and inflammatory bowel diseases.
Review in Alimentary pharmacology & therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07259603 (Association Between Vitamin D Deficiency and Disease Activity in Patients With Inflammatory Bowel Disease), which is not on this map. Cited by 102 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Vitamin D Deficiency and Disease Activity in Patients With Inflammatory Bowel Disease
Who cites it
102 citing papers in PubMed, 8 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- The effects of steroid treatment on osteoporosis in patients with inflammatory bowel disease: A systematic review and meta-analysis.Medicine · 2026Pooled it
- From nutritional intervention to immune modulation: a multi-database bibliometric and topic modeling study of vitamin D in inflammatory bowel disease.Frontiers in immunology · 2026Pooled it
- The association between vitamin D status and inflammatory bowel disease among children and adolescents: A systematic review and meta-analysis.Frontiers in nutrition · 2022Pooled it
- Predefined Diets in Patients with Inflammatory Bowel Disease: Systematic Review and Meta-Analysis.Nutrients · 2020Pooled it
- Dietary intake of fish, n-3 polyunsaturated fatty acids, and risk of inflammatory bowel disease: a systematic review and meta-analysis of observational studies.European journal of nutrition · 2020Pooled it
- Vitamin D receptor FokI polymorphism and the risks of colorectal cancer, inflammatory bowel disease, and colorectal adenoma.Scientific reports · 2018Pooled it
- Association Between Inflammatory Bowel Disease and Vitamin D Deficiency: A Systematic Review and Meta-analysis.Inflammatory bowel diseases · 2015Pooled it
- Pooled it
- The effects of two vitamin D regimens on ulcerative colitis activity index, quality of life and oxidant/anti-oxidant status.Nutrition journal · 2019Trial
- Effects of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentrations in Cirrhotic Patients: A Randomized Controlled Trial.Nutrients · 2016Trial
- Pilot Study Evaluating Efficacy of 2 Regimens for Hypovitaminosis D Repletion in Pediatric Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2016Trial
- The Real-World Impact of Vitamin D Supplementation on Inflammatory Bowel Disease Clinical Outcomes.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Article
- Racial disparities in prevalence, screening, and complications of osteoporosis in patients with inflammatory bowel disease: a retrospective cohort study.Crohn's & colitis 360 · 2026Article
- Importance of vitamin D in gastrointestinal health and disease.Frontiers in nutrition · 2026Review
- Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications.Nutrients · 2025Review
- Targeting the Endocannabinoidome: A Novel Approach to Managing Extraintestinal Complications in Inflammatory Bowel Disease.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Bone Health in Paediatric Inflammatory Bowel Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Spondyloarthritis in First-Degree Relatives and Spouses of Patients with Inflammatory Bowel Disease: A Nationwide Population-based Cohort Study from Sweden.Journal of Crohn's & colitis · 2024Article
- Vitamin D and CRP are associated in hospitalized inflammatory bowel disease (IBD) patients in Shanghai.Asia Pacific journal of clinical nutrition · 2024Article
- Review
42 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundVitamin D is traditionally associated with bone metabolism. The immunological effects of vitamin D have increasingly come into focus.
aimTo review the evidence supporting a role of vitamin D in inflammatory bowel diseases.
methodsA comprehensive search was performed on PubMed using the terms 'crohn's disease' 'ulcerative colitis' and 'vitamin D'.
resultsVitamin D deficiency is common in patients with inflammatory bowel diseases (IBD) (16-95%) including those with recently diagnosed disease. Evidence supports immunological role of vitamin D in IBD. In animal models, deficiency of vitamin D increases susceptibility to dextran sodium sulphate colitis, while 1,25(OH)2 D3 ameliorates such colitis. One prospective cohort study found low predicted vitamin D levels to be associated with an increased risk of Crohn's disease (CD). Limited data also suggest an association between low vitamin D levels and increased disease activity, particularly in CD. In a large cohort, vitamin D deficiency (<20 ng/mL) was associated with increased risk of surgery (OR 1.8, 95% CI 1.2-2.5) in CD and hospitalisations in both CD (OR 2.1, 95% CI 1.6-2.7) and UC (OR 2.3, 95% CI 1.7-3.1). A single randomised controlled trial demonstrated that vitamin D supplementation may be associated with reduced frequency of relapses in patients with CD compared with placebo (13% vs. 29%, P = 0.06).
conclusionsThere is growing epidemiological evidence to suggest a role for vitamin D deficiency in the development of IBD and also its influence on disease severity. The possible therapeutic role of vitamin D in patients with IBD merits continued investigation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.